24342-60-7

Basic information

• Product Name: 1-[(4-CHLOROPHENYL)PHENYLMETHYL]HEXAHYDRO-1H-1,4-DIAZEPINE
• Synonyms: 1-[(4-CHLOROPHENYL)PHENYLMETHYL]HEXAHYDRO-1H-1,4-DIAZEPINE
• CAS NO: 24342-60-7
• Molecular Formula: C₁₈H₂₁ClN₂
• Molecular Weight: 300.83
• Mol File: 24342-60-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 407.2°C at 760 mmHg
• Flash Point: 200.1°C
• Appearance: /
• Density: 1.133g/cm³
• Vapor Pressure: 7.7E-07mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 1-[(4-CHLOROPHENYL)PHENYLMETHYL]HEXAHYDRO-1H-1,4-DIAZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-CHLOROPHENYL)PHENYLMETHYL]HEXAHYDRO-1H-1,4-DIAZEPINE(24342-60-7)
• EPA Substance Registry System: 1-[(4-CHLOROPHENYL)PHENYLMETHYL]HEXAHYDRO-1H-1,4-DIAZEPINE(24342-60-7)

Safety Data

• Hazardous Substances Data: 24342-60-7(Hazardous Substances Data)

Usage

Explanation

The compound is composed of 19 carbon atoms, 23 hydrogen atoms, 1 chlorine atom, and 2 nitrogen atoms.
2. Heterocyclic compound

Explanation

It contains a six-membered ring with two nitrogen atoms, making it a heterocyclic compound.

Explanation

The compound has a specific arrangement of atoms, with a 1,4-diazepine ring fused to a phenyl group and a 4-chlorophenyl group.
4. Pharmaceutical synthesis

Explanation

It is used in the synthesis of various pharmaceuticals and organic compounds.
5. Medicinal chemistry and drug development

Explanation

The compound has potential applications in medicinal chemistry and drug development due to its specific structural and chemical properties.

Explanation

The compound is known for its potential biological activities, making it an important chemical compound in the field of pharmaceutical research and development.
7. Potential therapeutic applications

Explanation

Due to its biological activities, the compound may be used in the development of new drugs for treating various diseases, including inflammation, cancer, and other conditions.

Chemical structure

1-[(4-Chlorophenyl)phenylmethyl]hexahydro-1H-1,4-diazepine

Biological activities

Anti-inflammatory, anti-tumor, and anti-cancer properties

InChI:InChI=1/C18H21ClN2/c19-17-9-7-16(8-10-17)18(15-5-2-1-3-6-15)21-13-4-11-20-12-14-21/h1-3,5-10,18,20H,4,11-14H2

Upstream product

• 505-66-8 1,4-Diazacycloheptane 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 

Downstream Products

• 1026940-01-1 3-{4-[(4-Chloro-phenyl)-phenyl-methyl]-[1,4]diazepan-1-yl}-N-(2-hydroxy-5-methyl-phenyl)-propionamide 
• 145600-96-0 2-[3-(4-benzhydrylpiperazino)propionyl]amino-4-methylphenol 
• 1224255-48-4 (Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)-1,4-diazepan-1-yl)-N-(4-phenylbutan-2-yl)-4-oxobut-2-enamide 
• 1224255-42-8 (Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)-1,4-diazepan-1-yl)-N-(4-methylbenzyl)-4-oxobut-2-enamide 
• 1224255-44-0 (Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)-1,4-diazepan-1-yl)-N-(4-methoxybenzyl)-4-oxobut-2-enamide 

Relevant articles and documents

Synthesis, Structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds

We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum (Burgess, S. J.; Selzer, A.; Kelly, J. X.; Smilkstein, M. J.; Riscoe, M. K.; Peyton, D. H. J. Med. Chem. 2006, 49, 5623. Andrews, S.; Burgess, S. J.; Skaalrud, D.; Kelly, J. X.; Peyton, D. H. J. Med. Chem. 2010, 53, 916). Here, we present an investigation into the Structure-activity relationship of the RCQ structures, resulting in an orally active molecule with good in vitro and in vivo antimalarial activity. We also present evidence of the mode of action, indicating that the RCQ molecules inhibit hemozoin formation in the parasite's digestive vacuole in a manner similar to that of chloroquine.