24356-94-3

Basic information

• Product Name: Algestone acetophenide
• Synonyms: 16,17-((1-phenylethylidene)bis(oxy))pregn-4-ene-3,20-dione;16-alpha,17-alpha-dihydroxyprogesteroneacetophenide;16-alpha,17-dihydroxypregn-4-ene-3,20-dionecyclicacetalwithacetophenone;17-((1-phenylethylidene)bis(oxy))-20-dion(16-alpha(r))-pregn-4-ene-16;20-dione,16-alpha,17-dihydroxy-pregn-4-ene-cyclicacetalwithacetophenone;alphasoneacetophenide;bovitrol;deladroxone
• CAS NO: 24356-94-3
• Molecular Formula: C₂₉H₃₆O₄
• Molecular Weight: 448.59
• EINECS: 246-195-8
• Mol File: 24356-94-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 150-151°
• Boiling Point: 477.29°C (rough estimate)
• Flash Point: 246.7 °C
• Appearance: /
• Density: 1.0455 (rough estimate)
• Vapor Pressure: 2.11E-13mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: Algestone acetophenide(CAS DataBase Reference)
• NIST Chemistry Reference: Algestone acetophenide(24356-94-3)
• EPA Substance Registry System: Algestone acetophenide(24356-94-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 24356-94-3(Hazardous Substances Data)

Usage

Description

Algestone acetophenide is a progestational steroid that is known for its ability to influence the reproductive system and has been demonstrated to have effects on milk and serum proteins in goats, as well as on the weight gain of kids. It is characterized by its use as an injectable steroid contraceptive in certain regions.

Uses

Used in Pharmaceutical Industry:
Algestone acetophenide is used as a progestin for its contraceptive effects, particularly in the form of an injectable steroid. It serves as a hormonal regulator to prevent pregnancy.
Used in Veterinary Medicine:
In the context of veterinary medicine, Algestone acetophenide is used to increase the proteins in milk and serum in goats, which can be beneficial for the overall health and productivity of the animals. Additionally, it is utilized to decrease the weight gain of kids, which can be advantageous for managing their growth and development.
Brand names associated with Algestone acetophenide include Deladroxone (Bristol-Myers Squibb) and Droxone (Bristol-Myers Squibb), indicating its commercial availability and application in the pharmaceutical market.

Originator

Neolutin Depo, Medici ,Italy ,1982

Manufacturing Process

To a suspension of 500 mg of 16α,17α-dihydroxyprogesterone in 25 ml of freshly redistilled acetophenone is added 0.125 ml of 72% perchloric acid and the mixture is agitated at room temperature for one hour. The clear solution is washed with dilute sodium bicarbonate to remove excess acid and the acetophenone layer, after addition of chloroform is separated from the aqueous phase. The organic layer is dried over sodium sulfate and after removal of the chloroform and acetophenone in high vacuum the residue is crystallized from 95% alcohol. The pure acetophenone derivative has a melting point of about 142°C to 144°C.

Therapeutic Function

Progestin, Contraceptive

InChI:InChI=1/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1