24377-08-0

Basic information

• Product Name: Pregna-4,14-diene-3,20-dione
• Synonyms: Pregna-4,14-diene-3,20-dione;Progesterone EP Impurity A;(8R,9S,10R,13R,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
• CAS NO: 24377-08-0
• Molecular Formula: C21H28O2
• Molecular Weight: 312.44582
• Product Categories: Steroids
• Mol File: 24377-08-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pregna-4,14-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: Pregna-4,14-diene-3,20-dione(24377-08-0)
• EPA Substance Registry System: Pregna-4,14-diene-3,20-dione(24377-08-0)

Safety Data

• Hazardous Substances Data: 24377-08-0(Hazardous Substances Data)

Usage

Uses

Progesterone derivative

Upstream product

• 115758-64-0 15α-(toluene-4-sulfonyloxy)-pregn-4-ene-3,20-dione 
• 95118-97-1 pregna-5,14-diene-3β,20β_F-diol 
• 16031-66-6 14-hydroxy-4-pregnene-3,20-dione 
• 600-73-7 15α-hydroxyprogesterone 
• 600-73-7 15β-hydroxypregn-4-ene-3,20-dione 
• 22042-13-3 3β-hydroxy-5,14-pregnadien-20-one 
• 19591-56-1 3β-Acetoxypregna-5,14-dien-20-one 
• 5186-13-0 3-Hydroxypregna-5,14,16-triene-20-one 
• 2453-93-2 3β-Acetoxypregna-5,14,16-trien-20-one 
• 72136-87-9 3β-acetoxy-5,6ξ-dibromo-5ξ-pregn-16-en-20-one 
• 979-02-2 16-dehydropregnenolone acetate 
• 57-83-0 progesterone 
• 57-83-0 Progesterone 

Relevant articles and documents

Progesterone derivatives that bind to the digitalis receptor: Synthesis of 14β-hydroxyprogesterone. A novel steroid with positive inotropic activity

The synthesis of 14-hydroxy-14β-pregn-4-ene-3,20-dione (14β-hydroxyprogesterone) is described. This novel steroid is about 10 times more potent than progesterone and one-tenth as potent as ouabagenin in an [3H]ouabain radioligand binding assay and is the first in a series of progesterone congeners that interact at the cardiac glycoside receptor both to posses the C/D cis ring junction and to enhance contractility of isolated cardiac tissue.

IMPROVED PREPARATION OF 14β-HYDROXYPROGESTERONE

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