24394-14-7 Usage
Description
(2Z,4E)-3-Methyl-5-[(1S)-1β-hydroxy-2,6-dimethyl-6β,2β-(epoxymethano)-4-oxocyclohexane-1-yl]-2,4-pentadienoic acid, also known as cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), is a naturally-occurring prostaglandin and a metabolite of prostaglandin D2. It possesses anti-inflammatory and anti-cancer properties, as well as the ability to regulate immune responses and lipid metabolism. 15d-PGJ2 has been studied for its potential therapeutic applications in treating various diseases, including diabetes, neurodegenerative disorders, and cardiovascular diseases. It is also being investigated for its ability to modulate inflammatory pathways and influence the development and progression of cancer.
Used in Pharmaceutical Industry:
(2Z,4E)-3-Methyl-5-[(1S)-1β-hydroxy-2,6-dimethyl-6β,2β-(epoxymethano)-4-oxocyclohexane-1-yl]-2,4-pentadienoic acid is used as a therapeutic agent for its anti-inflammatory and anti-cancer properties, as well as its role in regulating immune responses and lipid metabolism. It is being studied for its potential applications in treating various diseases, including diabetes, neurodegenerative disorders, and cardiovascular diseases.
Used in Cancer Research:
(2Z,4E)-3-Methyl-5-[(1S)-1β-hydroxy-2,6-dimethyl-6β,2β-(epoxymethano)-4-oxocyclohexane-1-yl]-2,4-pentadienoic acid is used as a research tool for investigating its ability to modulate inflammatory pathways and influence the development and progression of cancer. Its potential therapeutic applications in treating various types of cancer are being explored.
Used in Inflammation Management:
(2Z,4E)-3-Methyl-5-[(1S)-1β-hydroxy-2,6-dimethyl-6β,2β-(epoxymethano)-4-oxocyclohexane-1-yl]-2,4-pentadienoic acid is used as an anti-inflammatory agent for its ability to modulate inflammatory pathways and reduce inflammation in various conditions.
Used in Lipid Metabolism Regulation:
(2Z,4E)-3-Methyl-5-[(1S)-1β-hydroxy-2,6-dimethyl-6β,2β-(epoxymethano)-4-oxocyclohexane-1-yl]-2,4-pentadienoic acid is used as a regulator of lipid metabolism for its role in managing lipid levels and maintaining overall metabolic health.
Check Digit Verification of cas no
The CAS Registry Mumber 24394-14-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,3,9 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 24394-14:
(7*2)+(6*4)+(5*3)+(4*9)+(3*4)+(2*1)+(1*4)=107
107 % 10 = 7
So 24394-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O5/c1-10(6-12(17)18)4-5-15(19)13(2)7-11(16)8-14(15,3)20-9-13/h4-6,19H,7-9H2,1-3H3,(H,17,18)/b5-4+,10-6-/t13-,14-,15+/m1/s1
24394-14-7Relevant articles and documents
Analysis of isomerization process of 8'-hydroxyabscisic acid and its 3'- fluorinated analog in aqueous solutions
Todoroki, Yasushi,Hirai, Nobuhiro,Ohigashi, Hajime
, p. 1649 - 1653 (2007/10/03)
8'-Hydroxyabscisic acid (8'-HOABA), the first metabolite of abscisic acid (ABA) in plants, is spontaneously isomerized to low bioactive phaseic acid (PA). We investigated thermodynamic and kinetic properties of the isomerization process in aqueous solution buffered at the various pHs, along with the effects of 3'-fluorine. The 8'-HOABA/PA ratio at equilibrium was 2:98 at 25°C, while the 3'-fluoro-8'-HOABA/3'α-fluoro-PA ratio was 16:84, indicating that introduction of a fluorine at C-3' thermodynamically reduced isomerization of 8'-HOABA to PA. The isomerization became more rapid as pH increased; the rate constant at pH 10 was higher than that at pH 3 by a factor of 2000. Introduction of a fluorine at C-3' reduced the reaction rate by raising the activation enthalpy. This indicated that 8'-HOABA was also kinetically stabilized by the 3'-fluorine. These findings suggested that the control of pH and modification of the enone moiety of the ring would be useful to manipulate the catabolic inactivation rate of ABA. (C) 2000 Elsevier Science Ltd.
CHIRALITY OF THE ACYL GROUP OF β-HYDROXY-β-METHYLGLUTARYLHYDROXYABSCISIC ACID
Hirai, Nobuhiro,Koshimizu, Koichi
, p. 1867 - 1870 (2007/10/02)
The β-carbon of the acyl group of β-hydroxy-β-methylglutarylhydroxyabscisic acid was shown to possess R-configuration by HPLC analysis of the reduced product. - Keywords: Robina pseudacacia; Leguminosae; β-hydroxy-β-methylglutarylhydroxyabscisic acid; chirality; optical resolution; mevalonolactone.
