2441-41-0

Basic information

• Product Name: PALMITOYL GLYCINE
• Synonyms: N-palmitoylglycine;2-palMitaMidoacetic acid;Hexadecanoylaminoacetic acid;PalGly;Palmitoyl-glycine≥ 99% (TLC)
• CAS NO: 2441-41-0
• Molecular Formula: C₁₈H₃₅NO₃
• Molecular Weight: 313.48
• Mol File: 2441-41-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 121 °C(Solv: acetone (67-64-1))
• Boiling Point: 491.8°Cat760mmHg
• Flash Point: 251.2°C
• Appearance: white to off-white/
• Density: 0.96g/cm³
• Vapor Pressure: 5.13E-11mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: 2-8°C
• Solubility: DMSO: >10mg/mL
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: PALMITOYL GLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: PALMITOYL GLYCINE(2441-41-0)
• EPA Substance Registry System: PALMITOYL GLYCINE(2441-41-0)

Safety Data

• WGK Germany: 2
• Hazardous Substances Data: 2441-41-0(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22)

Upstream product

• 56-40-6 glycine 
• 112-67-4 n-hexadecanoyl chloride 
• 14464-31-4 palmitic acid N-succinimide ester 
• 6000-44-8 sodium glycinate 
• 59660-78-5 N-palmitoyl-glycine ethyl ester 
• 544-31-0 2-(palmitoylamino)ethanol 
• 111-57-9 N-stearoylethanolamine 
• 142-78-9 N-(2-hydroxyethyl)dodecanamide 
• 142-58-5 myristic monoethanolamide 
• 7112-02-9 N‐(2‐hydroxyethyl)octanamide 
• 7726-08-1 decanoic acid monoethanolamide 
• 57-10-3 1-hexadecylcarboxylic acid 
• 1206591-90-3 N-palmitoyl-Gly-OtBu 
• 214706-34-0 N-hexadecanoyl glycine methyl ester 

Downstream Products

• 133848-35-8 N-palmitoyl-glycine amide 

Relevant articles and documents

Long-acting entecavir prodrug and preparation method and application thereof

The invention relates to a long-acting entecavir prodrug and a preparation method and application thereof. The long-acting entecavir prodrug has a structure shown as formula I that is shown in the description; the long-acting entecavir prodrug can release slowly, continuously and stably in vivo and convert into an entecavir material technical, so that long acting is achieved. In the formula I, R1,R2 and R3 are defined the same as in the description.

Enzymic synthesis, physicochemical, and cell activity of glucosyl ester derivatives based on N-fatty acyl amino acid

Series of glucosyl esters derivatives were synthesized by enzymatic acylation and some surface properties, and cell activity were calculated and tested. The antitumor activity in vitro against three cancer cells, human colon carcinoma (K562), human hepatoma (HepG2), and human breast adenocarcinoma (MCF-7) of compounds, were evaluated using MTT methods. The glucosyl esters could significantly displayed high anticancer activity. Thereinto, compounds 12 and 12′ showed higher inhibition effect to cancer cells than others. Several compounds were more active than control drug 5-FU. The structure–activity relationship analysis revealed that lipophilic properties might be essential parameter for their activity.

Method for synthesizing fatty acyl glycocoll

The invention discloses a method for synthesizing fatty acyl glycocoll. The method comprises the steps that an oxidant, a catalyst promoter and an alkali solution are mixed into an aqueous solution, the aqueous solution is added into an organic solvent system formed by mixing fatty acid monoethanolamide and a catalyst, a reaction is carried out for 0.5-3 h under the condition of maintaining the pH of the whole mixed system to be 6.0-12.0 and the temperature to be 20-40 DEG C, then a reaction is carried out for 0.5-2 h under stirring, and a product containing fatty acyl glycocoll is obtained. According to the method for synthesizing fatty acyl glycocoll, the reaction speed and the product yield are high, the reaction condition is mild and easy to control, and the method for synthesizing fatty acyl glycocoll is efficient, conforms to environment-friendly chemistry and is capable of facilitating industrialized production.