24415-26-7Relevant articles and documents
PROCESS FOR THE DIRECT ALPHA-METHYLENATION OF KETONES
-
Page/Page column 16; 17, (2020/06/10)
The invention relates to a process for preparing an α-methylene ketone comprising the step of reacting a ketone with formaldehyde in the presence of a catalyst which is an organic compound comprising at least one acid function or the corresponding salt, ester or amide thereof and at least one amine function or the corresponding ammonium salt, or a zwitterion thereof.
Air-stable iron catalyst for the Oppenauer-type oxidation of alcohols
Moyer, Sara A.,Funk, Timothy W.
experimental part, p. 5430 - 5433 (2010/10/20)
An alcohol oxidation process using an air-stable iron tricarbonyl compound structurally similar to Shvo's diruthenium bridging hydride was developed. Secondary benzylic and allylic alcohols are oxidized in high yields, and evidence for an Oppenauer-type mechanism is presented.
1-Alkenylcycloalkoxy Radical Chemistry. A Two-Carbon Ring Expansion Methodology
Galatsis, Paul,Millan, Scott D.,Faber, Tim
, p. 1215 - 1220 (2007/10/02)
The exploitation of alkoxy radicals derived from 1-ethenylcycloalkanols for use in a two-carbon ring expansion protocol was proposed.Direct one-pot alkoxy radical-mediated fragmentation-cyclization was not feasible since the reactive intermediate was quenched by iodine in the reaction mixture.However, via the use of iodo epoxides 3, the tandem fragmentation-cyclization sequence could be accomplished.This afforded ring-expanded products via an endo mode of cyclization, although in one example product from an exo mode of cyclization was also isolated.This methodologywas shown to be valid for large ring compounds as well.The intermediary of iodo epoxides 3 also afforded improved yields as compared to the direct cyclization of iodo enones 4.These results are the first examples of radical cyclization to medium-sized carbocycles.