244151-81-3Relevant articles and documents
Pyrrolobenzimidazoles Linked to Heterocycles and Peptides. Design of DNA Base Pair Specific Phosphate Hydrolyzing Agents and Novel Cytotoxic Agents
Ghodousi, Arman,Huang, Xiaofen,Cheng, Zheng,Skibo, Edward B.
, p. 90 - 100 (2007/10/03)
Work in this laboratory has been involved with the design of aziridinyl quinone-based cancer drugs (PBIs) capable of both recognizing the DNA major groove and cleaving the phosphate backbone upon reduction to the hydroquinone. The hydroquinone species rec