244195-87-7

Basic information

• Product Name: (E)-5-Acetyl-7-oxo-oct-4-enoic acid methyl ester
• Synonyms: (E)-5-Acetyl-7-oxo-oct-4-enoic acid methyl ester
• CAS NO: 244195-87-7
• Molecular Weight: 212.246
• Mol File: 244195-87-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-5-Acetyl-7-oxo-oct-4-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-Acetyl-7-oxo-oct-4-enoic acid methyl ester(244195-87-7)
• EPA Substance Registry System: (E)-5-Acetyl-7-oxo-oct-4-enoic acid methyl ester(244195-87-7)

Safety Data

• Hazardous Substances Data: 244195-87-7(Hazardous Substances Data)

Upstream product

• 17559-81-8 (Z)-hex-3-ene-2,5-dione 
• 13013-02-0 methyl 4-nitrobutyrate 

Relevant articles and documents

2,5-Dialkylfurans and nitroalkanes as source of 2,3,5-trialkylpyrroles

The synthesis of 2,3,5-trialkylpyrroles can be easily achieved by conjugate addition of nitroalkanes to 2-alken-1,4-dione (prepared by oxidative cleavage of 2,5-dialkylfuran) in acetonitrile with DBU as base, followed by chemoselective hydrogenation (10% Pd/C as catalyst) of the C-C double bond of the enones obtained by the elimination of nitrous acid from the Michael adduct. The Paal-Knorr reaction, performed on a bed of basic alumina and in the absence of a solvent, completes the formation of the title compounds.