244236-52-0Relevant articles and documents
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring
Rajan, Remya,Schepmann, Dirk,Schreiber, Julian A.,Seebohm, Guiscard,Wünsch, Bernhard
, (2020/11/13)
Glutamatergic N-Methyl-D-aspartate (NMDA) receptors are heterotetrameric ion channels that can be comprised of different subunits. GluN2A subunit-containing NMDA receptors are associated with diseases like anxiety, depression, and schizophrenia. However,
NOVEL COMPOUNDS
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Page/Page column 69, (2016/04/20)
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.
HETEROCYCLIC INHIBITORS OF STEAROYL-COA DESATURASE
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Page/Page column 78-79, (2009/10/18)
The present invention provides heterocyclic derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising