244606-15-3

Basic information

• Product Name: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methylsulfanyl]-2-(naphthalene-2-sulfonylamino)-propionic acid
• Synonyms: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methylsulfanyl]-2-(naphthalene-2-sulfonylamino)-propionic acid
• CAS NO: 244606-15-3
• Molecular Weight: 583.729
• Mol File: 244606-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methylsulfanyl]-2-(naphthalene-2-sulfonylamino)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methylsulfanyl]-2-(naphthalene-2-sulfonylamino)-propionic acid(244606-15-3)
• EPA Substance Registry System: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methylsulfanyl]-2-(naphthalene-2-sulfonylamino)-propionic acid(244606-15-3)

Safety Data

• Hazardous Substances Data: 244606-15-3(Hazardous Substances Data)

Upstream product

• 177582-20-6 NSC₁₂₃₅₂₈ 
• 93-11-8 2-Naphthalenesulfonyl chloride 

Downstream Products

• 754964-10-8 N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide 
• 774524-52-6 N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-3-mercapto-2-(naphthalene-2-sulfonylamino)-propionamide 

Relevant articles and documents

Design and synthesis of a novel synthetic NAPAP-pentasaccharide conjugate displaying a dual antithrombotic action

The synthesis of a novel antithrombotic consisting of a heparin pentasaccharide conjugated to the active site inhibitor N-(2- naphtalenesulfonyl)-glycyl-(D)-4-aminophenyl-alanyl-piperidine (NAPAP) (i.e. compound I) is reported. This conjugate shows a unique pharmacological profile both in vitro and in vivo having direct anti-thrombin and ATIII- mediated anti-Xa activity. Furthermore, conjugate I has a prolonged in vivo half-life compared to NAPAP (1.5 h vs 9 min.).