24464-41-3

Basic information

• Product Name: 7-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 7-phenyl-1,2,3,4-tetrahydroisoquinoline;1,2,3,4-tetrahydro-7-phenylIsoquinoline
• CAS NO: 24464-41-3
• Molecular Formula: C₁₅H₁₅N
• Molecular Weight: 209.2863
• Mol File: 24464-41-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-phenyl-1,2,3,4-tetrahydroisoquinoline(24464-41-3)
• EPA Substance Registry System: 7-phenyl-1,2,3,4-tetrahydroisoquinoline(24464-41-3)

Safety Data

• Hazardous Substances Data: 24464-41-3(Hazardous Substances Data)

Usage

General Description

7-phenyl-1,2,3,4-tetrahydroisoquinoline is a chemical compound with a molecular formula C16H15N. It is a colorless to pale yellow liquid that is soluble in organic solvents. 7-phenyl-1,2,3,4-tetrahydroisoquinoline is commonly used in the synthesis of pharmaceuticals and as a building block in organic chemistry. It has been studied for its potential medicinal properties, including its potential as an anti-inflammatory and analgesic agent. 7-phenyl-1,2,3,4-tetrahydroisoquinoline has also been investigated for its neuroprotective and antioxidant effects, making it a compound of interest in the field of medicinal chemistry.

Upstream product

• 70125-65-4 7-phenylisoquinoline 
• 75416-46-5 Biphenyl-3-ylmethyl-(2-chloro-ethyl)-amine; hydrochloride 
• 34784-06-0 7-chloroisoquinoline 
• 58794-09-5 7-bromoisoquinoline 
• 98-80-6 phenylboronic acid 

Downstream Products

• 189744-53-4 2-methyl-5-(7-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine 

Relevant articles and documents

Ruthenium-catalyzed chemo-and enantioselective hydrogenation of isoquinoline carbocycles

A chemoselective hydrogenation of isoquinoline carbocycles was achieved by using the catalyst prepared from Ru(methallyl)2(cod) and trans-chelate chiral ligand PhTRAP. The unique chemoselectivity achieved in this hydrogenation could be ascribed to the trans-chelation of the chiral ligand. The procedure for preparing the catalyst strongly affects the reproducibility of the carbocycle hydrogenation. Various 5-, 6-, 7-, and 8-substituted isoquinolines were selectively hydrogenated at their carbocycles to afford 5,6,7,8-tetrahydroisoquinolines as major products in high yields with moderate or good enantioselectivities. Some mechanistic studies suggested that the stereogenic center was created during the initial addition of H2 to the aromatic ring in the hydrogenation of 5-substituted isoquinolines. In other words, the stereochemical control was accompanied by the dearomatization.

Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists

The present invention relates to urotensin II receptor antagonists, pharmaceutical compositions containing them and their use.

PYRROLO-PYRIDINE DERIVATIVES

Compounds of formula I are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia. STR1 wherein Q is STR2