24486-66-6

Basic information

• Product Name: 1-methyl-3-(phenylmethyl)-1H-indole
• Synonyms: 1-methyl-3-(phenylmethyl)-1H-indole
• CAS NO: 24486-66-6
• Molecular Weight: 221.302
• Mol File: 24486-66-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-methyl-3-(phenylmethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-3-(phenylmethyl)-1H-indole(24486-66-6)
• EPA Substance Registry System: 1-methyl-3-(phenylmethyl)-1H-indole(24486-66-6)

Safety Data

• Hazardous Substances Data: 24486-66-6(Hazardous Substances Data)

Usage

General Description

1-methyl-3-(phenylmethyl)-1H-indole is a chemical compound with a molecular formula C20H19N. It is an indole derivative with a methyl group and a phenylmethyl group attached to the 1 and 3 positions, respectively. 1-methyl-3-(phenylmethyl)-1H-indole is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities. It may have applications in drug development, as well as in the study of serotonin receptors and related pathways. Further research is needed to fully understand its pharmacological properties and potential therapeutic uses.

Upstream product

• 603-76-9 1-methylindole 
• 100-39-0 benzyl bromide 
• 536-74-3 phenylacetylene 
• 54655-08-2 N,N-dimethyl-2-(2-phenylethynyl)aniline 
• 100-44-7 benzyl chloride 
• 16886-10-5 3-benzyl-1H-indole 
• 74-88-4 methyl iodide 
• 100-46-9 benzylamine 
• 19012-03-4 N-methyl-3-formylindole 
• 1589-82-8 phenylmagnesium bromide 
• 1908-67-4 (1-methyl-1H-indol-3-yl)(phenyl)methanol 
• 100-51-6 benzyl alcohol 
• 122-97-4 3-Phenyl-1-propanol 
• 618-40-6 1-Methyl-1-phenylhydrazine 

Downstream Products

• 1592481-97-4 ((4aS,9aS)-4a-benzyl-9-methyl-3-phenyl-4,4a,9,9a-tetrahydro-1H-pyridazino[3,4-b]indol-1-yl)(phenyl)methanone 
• 19012-01-2 3-benzoyl-1-methylindole 

Relevant articles and documents

Intramolecular Addition of a Dimethylamino C(sp 3)-H Bond across C-C Triple Bonds Using IrCl(DTBM-SEGPHOS)(ethylene) Catalyst: Synthesis of Indoles from 2-Alkynyl- N -methylanilines

Intramolecular addition of a C(sp 3)-H bond of the dimethylamino group across the C-C triple bond in 2-alkynyl- N, N -dimethylanilines is effectively catalyzed by a new iridium complex, IrCl(DTBM-SEGPHOS)(C 2H 4), in mesitylene at 150 °C. The intramolecular C(sp 3)-H addition is followed by double-bond isomerization to afford 3-substituted indoles in good to high yields.

Indole-based allosteric inhibitors of HIV-1 integrase

Employing a scaffold hopping approach, a series of allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) have been synthesized based on an indole scaffold. These compounds incorporate the key elements utilized in quinoline-based ALLINIs for binding to the IN dimer interface at the principal LEDGF/p75 binding pocket. The most potent of these compounds displayed good activity in the LEDGF/p75 dependent integration assay (IC50?=?4.5?μM) and, as predicted based on the geometry of the five- versus six-membered ring, retained activity against the A128T IN mutant that confers resistance to many quinoline-based ALLINIs.

A highly efficient route to C-3 alkyl-substituted indoles via a metal-free transfer hydrogenation

A highly efficient route to C-3 alkyl-substituted indoles via completely metal-free catalytic transfer hydrogenation of 3-indolemethanols was developed. This process proceeds via vinylogous iminium intermediates formed in situ in the presence of Br?nsted