24490-31-1

Basic information

• Product Name: 1-(1-hydroxynaphthalen-2-yl)propan-1-one
• CAS NO: 24490-31-1
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 200.2332
• Mol File: 24490-31-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 347.1°C at 760 mmHg
• Flash Point: 147.8°C
• Density: 1.177g/cm³
• Vapor Pressure: 2.75E-05mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 1-(1-hydroxynaphthalen-2-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-hydroxynaphthalen-2-yl)propan-1-one(24490-31-1)
• EPA Substance Registry System: 1-(1-hydroxynaphthalen-2-yl)propan-1-one(24490-31-1)

Safety Data

• Hazardous Substances Data: 24490-31-1(Hazardous Substances Data)

Usage

Description

1-(1-hydroxynaphthalen-2-yl)propan-1-one, also known as 2'-Hydroxypropiophenone, is a chemical compound with the molecular formula C13H10O2. It is a ketone compound featuring a naphthyl group attached to the carbon atom adjacent to the carbonyl group. 1-(1-hydroxynaphthalen-2-yl)propan-1-one is recognized for its applications in organic synthesis and as a key component in the production of pharmaceuticals, agrochemicals, fragrances, and flavorings. Furthermore, it has been investigated for its potential biological and pharmacological properties, including anti-inflammatory and antioxidant effects.

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(1-hydroxynaphthalen-2-yl)propan-1-one is used as a building block for the synthesis of various pharmaceuticals and agrochemicals due to its unique chemical structure and reactivity. Its ability to be incorporated into complex molecules makes it a valuable asset in the development of new drugs and agricultural products.
Used in Fragrance and Flavoring Industries:
In the fragrance and flavoring industries, 1-(1-hydroxynaphthalen-2-yl)propan-1-one is utilized as a key component in the creation of various scents and tastes. Its distinctive chemical properties allow it to contribute to the development of unique and appealing fragrances and flavor profiles.
Used in Organic Synthesis:
As a versatile ketone compound, 1-(1-hydroxynaphthalen-2-yl)propan-1-one is employed in organic synthesis for the production of a wide range of chemical compounds. Its reactivity and structural features make it a suitable candidate for use in the synthesis of various organic molecules.
Used in Biological and Pharmacological Research:
1-(1-hydroxynaphthalen-2-yl)propan-1-one has been studied for its potential biological and pharmacological activities. It is used as a subject of research for its anti-inflammatory and antioxidant effects, which could lead to the development of new treatments for various conditions and diseases.

Upstream product

• 3121-71-9 α-naphthyl propionate 
• 90-15-3 α-naphthol 
• 802294-64-0 propionic acid 
• 133181-63-2 1-(4-hydroxy-[1]naphthyl)-propan-1-one 
• 123-62-6 propionic acid anhydride 
• 134643-89-3 1-(1-Hydroxy-3,4-dihydro-naphthalen-2-yl)-propan-1-one 
• 79-03-8 propionyl chloride 
• 7664-93-9 sulfuric acid 
• 861347-11-7 4-hydroxy-3-propionyl-naphthalene-1-sulfonic acid 
• 7732-18-5 water 
• 598-22-1 propanoyl bromide 
• 2216-69-5 1-Methoxynaphthalene 
• 123-38-6 propionaldehyde 

Downstream Products

• 73826-23-0 ω-<2-Propionyl-naphthyl-(1)-oxy>-aceton 
• 206117-08-0 2-{1-[(E)-Phenylimino]-propyl}-naphthalen-1-ol 
• 175692-57-6 1-anilino-1-(1'-hydroxy-2'-naphthyl)propane 
• 605-69-6 1-hydroxy-2,4-dinitronaphthalene 

Relevant articles and documents

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Synthesis of 2-acylphenol and flavene derivatives from the ruthenium-catalyzed oxidative c-h acylation of phenols with aldehydes

The cationic ruthenium hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4- has been found to be an effective catalyst for the oxidative C-H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C-H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts. A cationic ruthenium hydride complex catalyzes the oxidative C-H coupling of phenols with aldehydes to form 2-acylphenol and flavene derivatives.

Solvent affected facile synthesis of hydroxynaphthyl ketones: Lewis acids promoted Friedel-Crafts and demethylation reaction

Hydroxynaphthyl ketones were obtained with high yields under very mild conditions in the presence of AlCl3 via Friedel-Crafts acylation and demethylation from naphthyl ethers. Several Lewis acids were tested, and AlCl3 was the most efficient catalyst. Copyright Taylor & Francis Group, LLC.

Rare Earth Metal Complexes as Water-Tolerant Lewis Acid Catalysts in Organic Synthesis

Rare earth metal triflates are stable in aqueous media and can act as Lewis acid catalysts in several carbon-carbon bond forming reactions. This article describes some of these reactions; aldol and Mannich-type reactions in aqueous solution, and Friedel-Crafts acylations and Fries rearrangement in organic solvents. The reactions proceeded smoothly in the presence of a catalytic amount of the triflate under mild conditions. Moreover, the catalysts could be recovered after the reactions were completed and could be reused.