2453-91-0

Basic information

• Product Name: N-(4,4-diethoxybutyl)benzamide
• Synonyms: N-(4,4-diethoxybutyl)benzamide
• CAS NO: 2453-91-0
• Molecular Weight: 265.353
• Mol File: 2453-91-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4,4-diethoxybutyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4,4-diethoxybutyl)benzamide(2453-91-0)
• EPA Substance Registry System: N-(4,4-diethoxybutyl)benzamide(2453-91-0)

Safety Data

• Hazardous Substances Data: 2453-91-0(Hazardous Substances Data)

Upstream product

• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 98-88-4 benzoyl chloride 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 137521-24-5 4-(benzoylamino)butanal 
• 1312573-16-2 N-(4,4-diphenylbutyl)benzamide 
• 956-09-2 6-(benzoylamino)hexanoic acid 

Relevant articles and documents

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.