245442-82-4

Basic information

• Product Name: ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate
• Synonyms: ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate
• CAS NO: 245442-82-4
• Molecular Weight: 294.466
• Mol File: 245442-82-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate(245442-82-4)
• EPA Substance Registry System: ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate(245442-82-4)

Safety Data

• Hazardous Substances Data: 245442-82-4(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 22446-38-4 ethyl 3-hydroxyphenylacetate 

Downstream Products

• 245442-93-7 benzyl 2-[5-(tert-butyldimethylsilyl)-2-iodophenyl]ethyl selenide 
• 245442-84-6 tert-butyldimethylsilyl 4-iodo-3-(2-mesyloxyethyl)phenyl ether 
• 245442-92-6 tert-butyldimethylsilyl 4-iodo-3-(2-iodoethyl)phenyl ether 
• 245442-83-5 tert-butyldimethylsilyl 3-(2-hydroxyethyl)-4-iodophenyl ether 
• 342900-30-5 4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether 
• 342900-29-2 4-bromo-3-(2-hydroxyethyl)phenyl tert-butyldimethylsilyl ether 
• 342900-28-1 ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate 
• 160701-58-6 tert-butyldimethylsilyl 3-(2-hydroxyethyl)phenyl ether 

Relevant articles and documents

Toward Novel Antioxidants: Preparation of Dihydrotellurophenes and Selenophenes by Alkyltelluride-Mediated Tandem SRN1/SHi Reactions

Reaction of 1-(2-iodophenyl)-1-methyloxirane (12) with 2 equiv of sodium n-butyltellurolate (n-BuTeNa), generated by the sodium borohydride reduction of di-n-butyl ditelluride, in THF, affords 2,3-dihydro-3-hydroxy-3-methylbenzo[b]tellurophene (13) in 62% yield, together with a small quantity of 1-(n-butyltelluro)-2-phenyl-2-propanol (27). This transformation presumably involves a tandem SRN1/SHi sequence. Similar reactions of 1-(benzylseleno)-2-phenyl-2-propanol (5a, R = Me) and 1-allyloxy-2-iodobenzene (15) afforded 2,3-dihydro-3-hydroxy-3-methylbenzo[b]selenophene (17, 74%), and 3-(n-butyltelluro)methyl-2,3-dihydrobenzo[b]furan (18, 50%), respectively. Lithium alkyltellurolates, generated by direct tellurium insertion into the required alkyllithium, or sec-butyl or tert-butyl substitution on tellurium provide product distributions similar to those observed for reactions involving n-BuTeNa. Lithium or sodium phenyltellurolate returned only starting materials from these reaction mixtures. The 2-[2-(n-butyltelluro)-1-hydroxy-1-methyl]ethylphenyl radical (14) is estimated to cyclize with kc 5 × 108 s-1 at 25 °C. The tandem SRN1/SHi sequence has been applied to the preparation of the antioxidant analogues, 5-hydroxy-2,3-dihydrobenzo[b]- tellurophene and selenophene (31, 32).

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.