245554-93-2

Basic information

• Product Name: 2(1H)-Quinoxalinone, 3,4-dihydro-3-(phenylmethyl)-, (3S)-
• CAS NO: 245554-93-2
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• Mol File: 245554-93-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinoxalinone, 3,4-dihydro-3-(phenylmethyl)-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone, 3,4-dihydro-3-(phenylmethyl)-, (3S)-(245554-93-2)
• EPA Substance Registry System: 2(1H)-Quinoxalinone, 3,4-dihydro-3-(phenylmethyl)-, (3S)-(245554-93-2)

Safety Data

• Hazardous Substances Data: 245554-93-2(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 952060-26-3 N-(2-nitrophenyl)-phenylalanine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 6613-41-8 ethyl 3-phenylpyruvate 
• 95-54-5 1,2-diamino-benzene 
• 615-36-1 2-bromoaniline 
• 1132769-58-4 (2S)-2-(2-nitrophenylamino)-3-phenylpropionic acid methyl ester 

Downstream Products

• 1132769-71-1 C₂₃H₂₀N₂O₃ 
• 1261061-27-1 C₂₆H₃₂N₂O₃ 

Relevant articles and documents

Iron- or Zinc-Mediated Synthetic Approach to Enantiopure Dihydroquinoxalinones

A general and efficient synthesis of enantiopure dihydroquinoxalinones has been developed using naturally occurring amino acids as starting materials. The reductive cyclization of N-(o-nitroaryl)amino esters was performed by using iron and zinc metal under mild conditions in a water/ethyl acetate mixture. The corresponding dihydroquinoxalinones were obtained in moderate to high yields and high enantiomeric purity, among which 7 new compounds were unprecedented in the literature.

Efficient synthesis of useful heterocycles via transition metal-catalyzed cascade processes

This paper reports our recent results from synthesis of some useful heterocycles, for example oxazolidinones, indoles, and quinoxalinones, by transition metal-catalyzed cascade processes. The scope and limitations of these procedures and the reaction mech

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs. The observed selectivity and potency (IC50 values 10-200 nM against HDAC6) is markedly dependent on the absolute configuration of the chiral moiety, and suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.