245657-01-6

Basic information

• Product Name: 4,4'-bis(pyridin-4-ylethynyl)-1,1'-biphenyl
• Synonyms: 4,4'-bis(pyridin-4-ylethynyl)-1,1'-biphenyl
• CAS NO: 245657-01-6
• Molecular Weight: 356.426
• Mol File: 245657-01-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4,4'-bis(pyridin-4-ylethynyl)-1,1'-biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-bis(pyridin-4-ylethynyl)-1,1'-biphenyl(245657-01-6)
• EPA Substance Registry System: 4,4'-bis(pyridin-4-ylethynyl)-1,1'-biphenyl(245657-01-6)

Safety Data

• Hazardous Substances Data: 245657-01-6(Hazardous Substances Data)

Upstream product

• 38215-38-2 4,4'-diethynylbiphenyl 
• 19524-06-2 4-bromopyridine hydrochloride 
• 1120-87-2 4-bromopyridin 
• 29619-44-1 4,4'-bis[(trimethylsilyl)ethynyl]biphenyl 
• 1244020-71-0 4-((4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethynyl)pyridine 
• 138517-19-8 (4'-iodophenyl)-(4-pyridyl)acetylene 
• 624-38-4 para-diiodobenzene 
• 2510-22-7 4-pyridylacetylene 
• 3001-15-8 4,4'-diiodobiphenyl 

Relevant articles and documents

The design and synthesis of bis-[4'-azido-2,2':6',2-terpyridine platinum(II)] complexes with rigid and extended linkers for studying the topology of DNA by photoaffinity labeling

A family of bis-[4'-Azido-2,2':6',2''-terpyridine platinum(II)] complexes with linear linkers of varying length have been synthesized. They have been designed to bis-intercalate into two DNA duplexes in close proximity, the azido groups allowing the sites of intercalation to be photoaffinity labeled. The linker to Pt(II) bonds are susceptible to cleavage by thiols and cyanide ion, which is a requirement for the intended method of analysis by 2D gel electrophoresis. (C) 1999 Academic Press.

The Covalent and Coordination Co-Driven Assembly of Supramolecular Octahedral Cages with Controllable Degree of Distortion

Discovering and constructing novel and fancy structures is the goal of many supramolecular chemists. In this work, we propose an assembly strategy based on the synergistic effect of coordination and covalent interactions to construct a set of octahedral s

Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators

A series of compounds based on the mGluR5-selective ligand 2-methyl-6-(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to be either structural analogues of MPEP, substituted monomers, or dimeric analogues. All compounds retained mGluR5 selectivity with only weak or no activity at other mGluRs or iGluRs. The substituted analogue, 1,3-bis(pyridin-2-ylethynyl)benzene (19), is a potent negative modulator at mGluR5, whereas all other compounds lost potency relative to MPEP and showed that activity is highly dependent on the position of the nitrogen atom in the pyridine moieties. A homology modeling and ligand docking study was used to understand the binding mode and the observed selectivity of compound 19.