24567-06-4

Basic information

• Product Name: 2-BROMO-1-(4-BROMO-PHENYL)-2-PHENYL-ETHANONE
• Synonyms: 2-BROMO-1-(4-BROMO-PHENYL)-2-PHENYL-ETHANONE
• CAS NO: 24567-06-4
• Molecular Formula: C₁₄H₁₀Br₂O
• Molecular Weight: 354.04
• Mol File: 24567-06-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 404.2 °C at 760 mmHg
• Flash Point: 113.3 °C
• Appearance: /
• Density: 1.671 g/cm³
• Vapor Pressure: 9.58E-07mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 2-BROMO-1-(4-BROMO-PHENYL)-2-PHENYL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(4-BROMO-PHENYL)-2-PHENYL-ETHANONE(24567-06-4)
• EPA Substance Registry System: 2-BROMO-1-(4-BROMO-PHENYL)-2-PHENYL-ETHANONE(24567-06-4)

Safety Data

• Hazardous Substances Data: 24567-06-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-(4-bromo-phenyl)-2-phenyl-ethanone is a organic compound with the molecular formula C14H10Br2O. It is a yellow solid compound that has a faint odor. This chemical is primarily used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is also used as an intermediate in the synthesis of organic dyes and pigments. Due to its bromo-phenyl and phenyl-ethanone functional groups, this compound is highly reactive and is often used in organic synthesis and research. It should be handled with care and stored in a well-ventilated area, away from heat and humidity.

InChI:InChI=1/C14H10Br2O/c15-12-8-6-11(7-9-12)14(17)13(16)10-4-2-1-3-5-10/h1-9,13H

Upstream product

• 2001-29-8 1-(4-bromophenyl)-2-phenyl-ethan-1-one 
• 108-86-1 bromobenzene 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 27893-81-8 4-(4-bromo-phenyl)-5-phenyl-3H-thiazole-2-thione 
• 23722-44-3 1-(4-Bromo-phenyl)-2-hydrazono-2-phenyl-ethanone 
• 88675-44-9 1-(4-Bromo-phenyl)-2-phenyl-2-piperidin-1-yl-ethanone 
• 88675-41-6 1-(4-bromophenyl)-2-morpholino-2-phenylethanone 
• 88675-47-2 2-Azepan-1-yl-1-(4-bromo-phenyl)-2-phenyl-ethanone 
• 492470-94-7 1-(4-bromo-phenyl)-2-(2-methoxy-phenylsulfanyl)-2-phenyl-ethanone 
• 848590-32-9 4-(4-bromophenyl)-5-phenylthiazol-2-amine 
• 405201-28-7 3-(4-bromo-phenyl)-2-phenyl-benzo[b]thiophen-7-ol 
• 492470-98-1 3-(4-bromo-phenyl)-7-methoxy-2-phenyl-benzo[b]thiophene 
• 492471-10-0 1-[3-(4-bromo-phenyl)-7-hydroxy-2-phenyl-benzo[b]thiophen-6-yl]-ethanone 
• 405201-34-5 3-(4-bromo-phenyl)-6-hydroxy-2-phenyl-9-oxa-1-thia-cyclopenta[a]naphthalen-8-one 

Relevant articles and documents

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors

Inhibition of the interactions of the tumor suppressor protein p53 with its negative regulators MDM2 in vitro and in vivo, representing a valuable therapeutic strategy for cancer treatment. The natural product chalcone exhibited moderate inhibitory activity against MDM2, thus based on the binding mode between chalcone and MDM2, a hit unsaturated pyrrolidone scaffold was obtained through virtual screening. Several unsaturated pyrrolidone derivatives were synthesized and biological evaluated. As a result, because the three critical hydrophobic pockets of MDM2 were occupied by the substituted-phenyl linked at the pyrrolidone fragment, compound 4 h demonstrated good binding affinity with the MDM2. Additionally, compound 4 h also showed excellent antitumor activity and selectivity, and no cytotoxicity against normal cells in vitro. The further antitumor mechanism studies were indicated that compound 4 h could successfully induce the activation of p53 and corresponding downstream p21 proteins, thus successfully causing HCT116 cell cycle arrest in the G1/M phase and apoptosis. Thus, the novel unsaturated pyrrolidone p53-MDM2 inhibitors could be developed as novel antitumor agents.

Synthesis and antimicrobial activity of a new class of methyleneamine- linked bis-heterocycles

A new class of methyleneamine-linked bis-heterocycles that exhibit antimicrobial activity was synthesized. Bromination of 1 followed by condensation with thiourea gave 3. The reaction of 3 with propargyl bromide in dry toluene under inert atmosphere led to the formation of 4. Its subsequent reaction with different aromatic azides 5 using CuSO4.5H 2O-sodiumascorbate system in a 2:1 mixture of water and tert-butylalcohol yielded the title compounds 6a-j in good yields. The identities of these compounds were confirmed following elemental analysis, IR, 1H, 13C NMR, and mass spectral studies. All the title compounds exhibited pronounced in vitro antibacterial and antifungal activities.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.