24578-06-1 Usage
Description
(2R,3S,4S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol, also known as L-threo-1-phenyl-2-palmitoylamino-3-morpholinopropan-1-ol, is a chiral molecule with a pyrrolidine structure and two hydroxyl groups. It has multiple stereocenters, consisting of two asymmetric carbon atoms. (2R,3S,4S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol is commonly used as a building block in the synthesis of various pharmaceuticals and chiral ligands for asymmetric catalysis. It has also been studied for its potential therapeutic properties, particularly in the treatment of cardiovascular-related diseases. Due to its stereochemistry and functional groups, this compound has shown high potential in medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Synthesis:
(2R,3S,4S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol is used as a building block for the synthesis of various pharmaceuticals. Its unique stereochemistry and functional groups make it a valuable component in the development of new drugs.
Used in Chiral Ligand Synthesis for Asymmetric Catalysis:
(2R,3S,4S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol is used as a chiral ligand in asymmetric catalysis. Its stereochemistry allows for the selective formation of enantiomers, which is crucial in the synthesis of chiral compounds.
Used in Cardiovascular Disease Treatment:
(2R,3S,4S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol has been studied for its potential therapeutic properties in the treatment of cardiovascular-related diseases. Its unique structure and functional groups may contribute to its efficacy in addressing these conditions.
Used in Medicinal Chemistry and Drug Development:
(2R,3S,4S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol is used in medicinal chemistry and drug development due to its high potential in these fields. Its stereochemistry and functional groups make it a promising candidate for the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 24578-06-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,7 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 24578-06:
(7*2)+(6*4)+(5*5)+(4*7)+(3*8)+(2*0)+(1*6)=121
121 % 10 = 1
So 24578-06-1 is a valid CAS Registry Number.
24578-06-1Relevant articles and documents
Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitors
Guazzelli, Lorenzo,D'Andrea, Felicia,Sartini, Stefania,Giorgelli, Francesco,Confini, Gianluca,Quattrini, Luca,Piano, Ilaria,Nencetti, Susanna,Orlandini, Elisabetta,Gargini, Claudia,La Motta, Concettina
supporting information, (2019/09/30)
Diabetes is a multi-factorial disorder that should be treated with multi-effective compounds. Here we describe the access to polyhydroxylated pyrrolidines, belonging to the D-gluco and D-galacto series, through aminocyclization reactions of two differenti
A SHORT, VERSATILE APPROACH TO POLYHYDROXYLATED PYRROLIDINES UTILIZING A REDUCTIVE ELIMINATION-REDUCTIVE AMINATION AS A KEY STEP
Bernotas, Ronald C.
, p. 469 - 472 (2007/10/02)
An efficient synthesis of epimeric alpha-vinyl pyrrolidines starting from methyl 4,6-O-benzyliden gluco- and galactopyranosides gave ready access to hydroxylated pyrrolidines.
SYNTHESIS OF 1,4-DIDEOXY-1,4-IMINO-D-GLUCITOL, A GLUCOSIDASE INHIBITOR
Kuszmann, Janos,Kiss, Laszlo
, p. 45 - 54 (2007/10/02)
1,2:5,6-Di-O-isopropylidene-D-glucitol was converted via its 1,4-dimethanesulfonate into the 1-azido-4-methanesulfonate which, after deprotection and treatment with barium hydroxide, afforded a 9:1 mixture of the corresponding 3,4- and 4,5-anhydro derivat
