24589-78-4 Usage
Description
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a versatile derivatizing reagent used in various applications, including pharmaceuticals and chemical analysis. It is a clear colorless to light yellow liquid and can be used as an alternative to diazomethane. MSTFA is an N-silyl compound in which the amide nitrogen of N-methyltrifluoroacetamide is replaced by a trimethylsilyl group.
Uses
Used in Pharmaceutical Industry:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a pharmaceutical intermediate for the synthesis of various drugs and compounds.
Used in Metabolite Analysis:
MSTFA is used as a metabolite of Famprofazone in humans, aiding in the study and analysis of drug metabolism.
Used in Gas Chromatography-Mass Spectrometry (GC-MS) Analysis:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis, enhancing the detection and identification of various compounds.
Used in Steroid Hormone Detection:
MSTFA is employed in the detection of steroid hormones such as 17-alfa-ethynylestradiol and estrone, playing a crucial role in endocrinology and hormone research.
Purification Methods
Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]
Check Digit Verification of cas no
The CAS Registry Mumber 24589-78-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,8 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 24589-78:
(7*2)+(6*4)+(5*5)+(4*8)+(3*9)+(2*7)+(1*8)=144
144 % 10 = 4
So 24589-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
24589-78-4Relevant articles and documents
Method of Synthesizing of N-methyl-N-trimethylsilyl trifluoroacetamide, N-methyl-N-trimethylsilyl trifluoroacetamide synthesized thereby and an electrolyte for lithium secondary battery including the same
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Paragraph 0021-0022; 0058-0059, (2016/12/16)
The present invention relates to a synthesis method of N-methyl-N-trimethylsilyl trifluoroacetamide (MSTFA), MSTFA synthesized thereby and an electrolyte for a lithium secondary battery including the same. The present invention comprises the steps of: preparing N-methyltrifluoroacetamide by using ethyltrifluoroacetate and methylamine; and obtaining MSTFA by separating and removing a precipitate from a reaction mixture obtained by introducing trimethylsilyl chloride to a mixture of N-methyltrifluoroacetamide and triethylamine. According to the present invention, since BSA (N,O-bis(trimethylsilyl)acetamide) is not used, it is relatively easy to remove a starting material and a side reaction material which are not reacted by fractional distillation. Therefore, it is possible to obtain a high-purity MSTFA of 99.0% or more and if the high-purity MSTFA of 99.0% or more is used as an additive of an electrolyte for a lithium secondary battery, it is possible to improve lifespan characteristics of a lithium secondary battery.COPYRIGHT KIPO 2015
Bis-trimethylsilyl cefamandole and process therefor
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, (2008/06/13)
Bis-trimethylsilyl cefamandole is useful for regenerating cefamandole of excellent purity.
