2461-83-8

Basic information

• Product Name: 1,4-Bis(4-bromophenyl)butane-1,4-dione
• Synonyms: 1,4-Bis(4-bromophenyl)-1,4-butanedione;1,4-Bis(4-bromophenyl)butane-1,4-dione
• CAS NO: 2461-83-8
• Molecular Formula: C₁₆H₁₂Br₂O₂
• Molecular Weight: 396.07
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 2461-83-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 182 °C(Solv: benzene (71-43-2))
• Boiling Point: 500.1°C at 760 mmHg
• Flash Point: 141.6°C
• Appearance: /
• Density: 1.611g/cm³
• Vapor Pressure: 3.91E-10mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane, Methanol
• CAS DataBase Reference: 1,4-Bis(4-bromophenyl)butane-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Bis(4-bromophenyl)butane-1,4-dione(2461-83-8)
• EPA Substance Registry System: 1,4-Bis(4-bromophenyl)butane-1,4-dione(2461-83-8)

Safety Data

• Hazardous Substances Data: 2461-83-8(Hazardous Substances Data)

Usage

Description

1,4-Bis(4-bromophenyl)butane-1,4-dione is an organic compound characterized by its white solid appearance. It is a derivative of butane-1,4-dione with two 4-bromophenyl groups attached to the 1,4-positions. 1,4-Bis(4-bromophenyl)butane-1,4-dione is known for its chemical stability and reactivity, making it a valuable intermediate in the synthesis of various pharmaceuticals and other organic compounds.

Uses

1. Used in Pharmaceutical Industry:
1,4-Bis(4-bromophenyl)butane-1,4-dione is used as an intermediate in the synthesis of Furamidine (F863600), which is an antimicrobial and antiparasitic agent. Its role in the preparation of Furamidine is crucial due to its unique chemical properties that facilitate the formation of the desired active pharmaceutical ingredient.
2. Used in Chemical Synthesis:
1,4-Bis(4-bromophenyl)butane-1,4-dione serves as a versatile building block in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its reactivity and stability make it a valuable component in the development of new molecules with specific biological activities or material properties.

InChI:InChI=1/C16H12Br2O2/c17-13-5-1-11(2-6-13)15(19)9-10-16(20)12-3-7-14(18)8-4-12/h1-8H,9-10H2

Upstream product

• 6332-09-8 1.4-bis-(4-bromo-phenyl)-butene-(2c)-dione-(1.4) 
• 6332-09-8 (E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione 
• 881650-48-2 (Z)-1,4-bis(4-bromophenyl)-2,3-dichlorobut-2-ene-1,4-dione 
• 881650-47-1 2.3-dichloro-1.4-bis-(4-bromo-phenyl)-butene-(2t)-dione-(1.4) 
• 881650-45-9 2.3-dibromo-1.4-bis-(4-bromo-phenyl)-butene-(2c)-dione-(1.4) 
• 881650-44-8 2.3-dibromo-1.4-bis-(4-bromo-phenyl)-butene-(2t)-dione-(1.4) 
• 165287-54-7 2,3-dibromo-1,4-bis-(4-bromo-phenyl)-butane-1,4-dione 
• 179118-20-8 2-(4-bromo-benzoyl)-4-(4-bromo-phenyl)-4-oxo-butyric acid ethyl ester 
• 99-73-0 para-bromophenacyl bromide 
• 93298-09-0 C₁₈H₁₈Br₂N₆O₂ 
• 75-16-1 methylmagnesium bromide 
• 64-19-7 acetic acid 
• 513-88-2 1,1-Dichloroacetone 
• 7716-86-1 1-(4-bromo-phenyl)-2,2-dichloro-ethanone 

Downstream Products

• 102892-96-6 ethyl 1-p-benzoate-2,5-di-p-bromopyrrole 
• 36710-35-7 2,5-bis(4-bromophenyl)furan 
• 63574-85-6 2,5-Bis(p-bromophenyl)thiophene 
• 61829-88-7 2,5-bis-(4-bromo-phenyl)-3,4-dichloro-furan 
• 101875-64-3 [2,5-bis-(4-bromo-phenyl)-pyrrol-1-yl]-acetic acid 
• 6332-09-8 (E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione 
• 91733-25-4 3,4-dibromo-2,5-bis-(4-bromo-phenyl)-furan 
• 70010-49-0 2, 5-bis(4-aminophenyl)thiophene 
• 924658-00-4 4,4'-dibromo-2,5-diphenyl-1,5-hexadiene 
• 1185200-12-7 2,5-bis(4-bromophenyl)-1-phenyl-1H-pyrrole 
• 1258232-63-1 2,5-bis(4-bromophenyl)-1-(4-tert-butylphenyl)-1H-pyrrole 
• 947325-91-9 (1R,4R)-1,4-bis(4-bromophenyl)butane-1,4-diol 

Relevant articles and documents

Copper(I)/DDQ-Mediated Double-Dehydrogenative Diels-Alder Reaction of Aryl Butenes with 1,4-Diketones and Indolones

A copper(I)/DDQ-mediated double-dehydrogenative Diels-Alder (DDDA) reaction of simple butenes with 1,4-diketones and indolones has been established for the first time. This strategy is based on a tandem double-dehydrogenation/Diels-Alder reaction from nonprefunctionalized starting materials, in which both a diene and dienophile were in situ generated via activation of fourfold inert C(sp3)-H bonds in one catalytic system.

Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO

A new facile method for the synthesis of β-keto sulfones employing xanthates, DMSO, and Fenton's reagent is described. The reaction proceeds under very mild conditions providing a cost-effective straightforward approach to various β-keto sulfones in high yields.

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum

Malaria is one of the most significant tropical diseases and remains a major challenge due to the lack of a broadly effective vaccine and parasite resistance to current drugs. This means there is a need for new drug candidates with novel modes of action.