24622-34-2

Basic information

• Product Name: 2-Benzothiazolamine,N-2-propenyl-(9CI)
• Synonyms: 2-Benzothiazolamine,N-2-propenyl-(9CI)
• CAS NO: 24622-34-2
• Molecular Formula: C10H10N2S
• Molecular Weight: 190.2648
• Product Categories: BENZOTHIAZOLE
• Mol File: 24622-34-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 299.5°Cat760mmHg
• Flash Point: 135°C
• Appearance: /
• Density: 1.236g/cm³
• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.695
• CAS DataBase Reference: 2-Benzothiazolamine,N-2-propenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolamine,N-2-propenyl-(9CI)(24622-34-2)
• EPA Substance Registry System: 2-Benzothiazolamine,N-2-propenyl-(9CI)(24622-34-2)

Safety Data

• Hazardous Substances Data: 24622-34-2(Hazardous Substances Data)

Usage

General Description

2-Benzothiazolamine, N-2-propenyl- (9CI) is a chemical compound with the molecular formula C11H9NS. It is a member of the benzothiazole family and contains a propenyl group. 2-Benzothiazolamine,N-2-propenyl-(9CI) is known to have various applications in the fields of pharmaceuticals, agriculture, and materials science. It is commonly used as an intermediate in the synthesis of various organic compounds. Its properties and reactivity make it a versatile building block for the production of a wide range of products. Additionally, it has been studied for its potential biological activities and may have applications in medicinal chemistry. Overall, 2-Benzothiazolamine, N-2-propenyl- (9CI) is an important chemical compound with diverse applications in research and industry.

InChI:InChI=1/C10H10N2S/c1-2-7-11-10-12-8-5-3-4-6-9(8)13-10/h2-6H,1,7H2,(H,11,12)

Upstream product

• 30719-59-6 N-allyl-N'-(2-amino-phenyl)-thiourea 
• 136-95-8 2-amino-benzthiazole 
• 201230-82-2 carbon monoxide 
• 106-95-6 allyl bromide 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 107-11-9 1-amino-2-propene 

Relevant articles and documents

Convenient and reliable routes towards 2-aminothiazoles: Palladium-catalyzed versus copper-catalyzed aminations of halothiazoles

Two efficient methods for the amination of 2-halothiazoles are presented here. A first protocol requires a Pd/L system. Several 2-aminothiazoles were synthesized under optimized conditions and isolated in good yields. The first palladium-catalyzed C-N coupling reactions between 2-halothiazoles and primary alkylamines are presented. In a second part, ligand-free copper-catalyzed aminations of 2-halothiazoles by alkylamines and aniline in a green solvent have been developed. The protocol is very effective for primary and secondary amines and perfectly tolerates the presence of another halide moiety on the 2-halothiazole. The reaction occurs under the assistance of microwave irradiation, which drastically decreases the reaction time. The reaction leads to the formation of 2-aminothiazoles, key molecules in pharmaceutical research. Copyright

Novel solid-phase parallel synthesis of N-substituted-2-aminobenzo [d]thiazole derivatives via cyclization reactions of 2-iodophenyl thiourea intermediate resin

A novel solid-phase methodology has been developed for the synthesis of N-alkyl, N-acyl, and N-sulfonyl-2-aminobenzo[d]thiazole derivatives. The key step in this procedure involves the preparation of polymer-bound 2-aminobenzo[d]thiazole resins 5 by cyclization reaction of 2-iodophenyl thiourea resin 3. The resin-bound 2-iodophenyl thiourea 3 is produced by addition of 2-iodophenyl isothiocyanate 2 to the amine-terminated linker amide resin 1. These core skeleton 2-aminobenzo[d]thiazole resins 5 undergo functionalization reactions with various electrophiles, such as alkyl halides, acid chlorides, and sulfonyl chlorides to generate N-alkyl, N-acyl, and N-sulfonyl-2-aminobenzo[d]thiazole resins 6, 7, and 8, respectively. Finally, N-alkyl, N-acyl, and N-sulfonyl-2-aminobenzo[d]thiazole derivatives 9, 10, and 11 are then generated in good yields and purities by cleavage of the respective resins 6, 7, and 8 using trifluoroacetic acid (TFA) in dichloromethane (DCM).