246224-53-3Relevant articles and documents
Modifications of the GSK3β substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics
Kayser, Katherine J.,Glenn, Matthew P.,Sebti, Said M.,Cheng, Jin Q.,Hamilton, Andrew D.
, p. 2068 - 2073 (2007)
Amplification, overexpression, and elevated activation of Akt have been detected in many human malignancies making it an important target for cancer therapy. The Akt substrate-binding site offers a large number of potential interactions to an appropriatel