24625-67-0

Basic information

• Product Name: Phosphinic amide, N-butyl-P,P-diphenyl-
• CAS NO: 24625-67-0
• Molecular Formula: C16H20NOP
• Molecular Weight: 273.315
• Mol File: 24625-67-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phosphinic amide, N-butyl-P,P-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic amide, N-butyl-P,P-diphenyl-(24625-67-0)
• EPA Substance Registry System: Phosphinic amide, N-butyl-P,P-diphenyl-(24625-67-0)

Safety Data

• Hazardous Substances Data: 24625-67-0(Hazardous Substances Data)

Upstream product

• 109-73-9 N-butylamine 
• 4559-70-0 Diphenylphosphine oxide 
• 1079-66-9 chloro-diphenylphosphine 
• 5994-87-6 diphenylphosphinamide 
• 71-36-3 butan-1-ol 
• 102817-54-9 4-cyanophenyl diphenylphosphinate 
• 99234-81-8 S-(4-nitrophenyl) diphenylphosphinothioate 
• 34253-14-0 3-nitro-o-phenyl phenyl(phenyl)phosphinate 
• 10259-20-8 4-nitrophenyl diphenylphosphinate 

Downstream Products

• 1707-03-5 diphenyl-phosphinic acid 
• 24625-68-1 N-butyl-P,P-diphenylphosphinothioic amide 
• 137171-51-8 2,4,6-tris(4-methoxyphenyl)-2,4,6-trisulfanylene-1,3,5,2,4,6-trioxatriphosphinane 

Relevant articles and documents

Practical Synthesis of Phosphinic Amides/Phosphoramidates through Catalytic Oxidative Coupling of Amines and P(O)?H Compounds

Herein, we report a highly efficient ZnI2-triggered oxidative cross-coupling reaction of P(O)?H compounds and amines. This operationally simple protocol provides unprecedented generic access to phosphinic amides/phosphoramidate derivatives in good yields and short reaction time. Besides, the reaction proceeds under mild conditions, which avoids the use of hazardous reagents, and is applicable to scale-up syntheses as well as late-stage functionalization of drug molecules. The stereospecific coupling is also achieved from readily available optically enriched P(O)?H compounds.

Direct conversion of secondary phosphine oxides and h-phosphinates with [Di(acyloxy)iodo]benzenes to phosphinic and phosphonic amides

The reaction of [di(acyloxy)iodo]- benzene with secondary phosphine oxides or H-phosphinates in the presence of primary or secondary amines allows one to obtain phosphinic or phosphonic acids amides in the one-pot process. We take advantage of the strong acylating system DAIB/R2P(O)H to phosphinylation of amines. However, the reaction mechanism is multipathway and causes yields of phosphinic or phosphonic acids amides to be moderate. When the concentration of amines is low, the intermolecular process plays a main role leading to the formation of carboxylic amides through mixed phosphoric-carboxylic anhydride, and also in the low concentration of amines, tetrahydrofuran effectively competes with the amines in the nucleophilic attack on the acylating intermediates.

One-Pot Phase-Transfer-Catalysed N-Alkylation of Diphenylphosphinamide with Alcohols in the Presence of Methanesulfonyl Chloride

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