2463-29-8

Basic information

• Product Name: Acetamide,N,N'-1,6-hexanediylbis[N-acetyl-
• Synonyms: Diacetamide,N,N'-hexamethylenebis- (6CI,7CI,8CI);N,N,N',N'-Tetraacetylhexamethylenediamine; NSC 377173
• CAS NO: 2463-29-8
• Molecular Formula: C14H24 N2 O4
• Molecular Weight: 284.356
• Mol File: 2463-29-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide,N,N'-1,6-hexanediylbis[N-acetyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide,N,N'-1,6-hexanediylbis[N-acetyl-(2463-29-8)
• EPA Substance Registry System: Acetamide,N,N'-1,6-hexanediylbis[N-acetyl-(2463-29-8)

Safety Data

• Hazardous Substances Data: 2463-29-8(Hazardous Substances Data)

Upstream product

• 3073-59-4 hexamethylene bisacetamide 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis[acetamide] analogues

Hexamethylenebis[acetamide] (HMBA) is an agent in clinical trial that induces differentiation of certain types of tumor cells to nonmalignant phenotypes. In an attempt to discover a more potent compound, a number of bis-functionalized amides, imides, and hydrazine derivatives of HMBA were prepared and evaluated in vitro with the HL-60 human promyelocytic leukemia cell line. Among the compounds evaluated, the 5,5-dimethylhydantoin derivative is almost 10 times more potent than HMBA in inducing differentiation. The bis-imide, diacetyl-HMBA is both more potent and effective than its parent compound. Six of the 16 compounds evaluated cause at least 20% differentiation. An inverse relationship between the degree of differentiation and the percentage of viable cells is described for HMBA and its analogues.