246868-60-0

Basic information

• Product Name: 2-Imidazolidinethione, 4,5-diphenyl-, (4S,5S)-
• CAS NO: 246868-60-0
• Molecular Formula: C15H14N2S
• Molecular Weight: 254.356
• Mol File: 246868-60-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Imidazolidinethione, 4,5-diphenyl-, (4S,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Imidazolidinethione, 4,5-diphenyl-, (4S,5S)-(246868-60-0)
• EPA Substance Registry System: 2-Imidazolidinethione, 4,5-diphenyl-, (4S,5S)-(246868-60-0)

Safety Data

• Hazardous Substances Data: 246868-60-0(Hazardous Substances Data)

Upstream product

• 16099-67-5 trans-4,5-diphenylimidazolidine-2-thione 
• 137618-04-3 1,3-diacetyl-trans-4,5-diphenylimidazolidine-2-thione 
• 75-15-0 carbon disulfide 
• 29841-69-8 (S,S)-1,2-diphenyl-1,2-diaminoethane 

Downstream Products

• 1169704-45-3 (S)-pentafluorophenyl 2-phenylbutanoate 
• 1262241-04-2 C₂₅H₂₄N₂OS 
• 1262241-17-7 C₂₅H₂₄N₂OS 
• 1262241-10-0 C₂₈H₃₀N₂OS 
• 1262241-11-1 C₄₁H₄₆N₂O₂S 

Relevant articles and documents

Development of Chiral Organosuperbase Catalysts Consisting of Two Different Organobase Functionalities

In the field of chiral Br?nsted base catalysis, a new generation of chiral catalysts has been highly anticipated to overcome the intrinsic limitation of pronucleophiles that are applicable to the enantioselective reactions. Herein, we reveal conceptually new chiral Br?nsted base catalysts consisting of two different organobase functionalities, one of which functions as an organosuperbase and the other as the substrate recognition site. Their prominent activity, which stems from the distinctive cooperative function by the two organobases in a single catalyst molecule, was demonstrated in the unprecedented enantioselective direct Mannich-type reaction of α-phenylthioacetate as a less acidic pronucleophile. The present achievement would provide a new guiding principle for the design and development of chiral Br?nsted base catalysts and significantly broaden the utility of Br?nsted base catalysis in asymmetric organic synthesis.

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.