247032-21-9

Basic information

• Product Name: Phenol, 4-fluoro-, carbonate (2:1)
• CAS NO: 247032-21-9
• Molecular Formula: C13H8F2O3
• Molecular Weight: 250.202
• Mol File: 247032-21-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phenol, 4-fluoro-, carbonate (2:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-fluoro-, carbonate (2:1)(247032-21-9)
• EPA Substance Registry System: Phenol, 4-fluoro-, carbonate (2:1)(247032-21-9)

Safety Data

• Hazardous Substances Data: 247032-21-9(Hazardous Substances Data)

Upstream product

• 371-41-5 4-Fluorophenol 
• 67-66-3 chloroform 
• 616-38-6 carbonic acid dimethyl ester 
• 38377-38-7 4-fluorophenyl chloroformate 
• 99553-79-4 2-(4-methoxyphenyl)-4-methyl-5-oxo-4,5-dihydrooxazole 
• 1379690-95-5 1-((4-fluorophenoxy)carbonyl)-2-iso-propyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidin-1-ium chloride 
• 36161-26-9 potassium 4-fluorophenoxide 
• 156148-49-1 p-nitrophenyl tris(p-fluorophenyl) orthocarbonate 
• 156420-94-9 tris(p-fluorophenoxy)methyl azide 

Relevant articles and documents

Photo-on-Demand Base-Catalyzed Phosgenation Reactions with Chloroform: Synthesis of Arylcarbonate and Halocarbonate Esters

Carbonate esters are utilized as solvents and reagents for C1 building blocks in organic synthesis. This study reports a novel photo-on-demand in situ synthesis of carbonate esters with CHCl3 solutions containing a mixture of an aromatic or haloalkyl alcohol having relatively high acidity, and an organic base. We found that the acid-base interaction of the alcohol and base in the CHCl3 solution plays a key role in enabling the photochemical reaction. This reaction allows practical syntheses of diphenyl carbonate derivatives, haloalkyl carbonates, and polycarbonates, which are important chemicals and materials in industry.

Isothiourea-mediated asymmetric O- to C-carboxyl transfer of oxazolyl carbonates: Structure-selectivity profiles and mechanistic studies

The structural motif within a series of tetrahydropyrimidine-based isothioureas necessary for generating high asymmetric induction in the asymmetric Steglich rearrangement of oxazolyl carbonates is fully explored, with crossover and dynamic 19F NMR experiments used to develop a mechanistic understanding of this transformation. Copyright

Prodrugs for amidines: Synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan

Syntheses of several carbamate analogues of 2,5-bis(4- amidinophenyl)furan (1) under mild conditions and their evaluation as prodrugs against Pneumocystis carinii pneumonia (PCP) in an immunosuppressed rat model are described. Thus, nine new bis-carbamates: methoxycarbonyl (2), 2,2,2-trichloroethoxycarbonyl (3), ethylthiocarbonyl (4), benzyloxycarbonyl (5), (4-methyl-2-oxo-1,3-dioxol-4-en-5-yl)methoxycarbonyl (6), phenoxycarbonyl (7), 4-fluorophenoxycarbonyl (8), 4-methoxyphenoxycarbonyl (9), and (1-acetoxy)ethoxycarbonyl (10) and a biscarbonate ethoxycarbonyloxy (1) of the bis-amidine 1 have been synthesized and evaluated. The in vivo results show that the 4-fluorophenyl carbamate 8 and the 4-methoxyphenyl carbamate 9 in this series had the best anti-PCP activity by both intravenous and oral administration at a dosage level of 22 mol and 33 μmol/kg/day, respectively. Compounds 3-7 were also more active than the parent drug (1) on oral administration. The acute toxicity usually exhibited by the parent amidine 1 at a dosage level of 22 μmol/kg/day on intravenous administration has been significantly reduced by the prodrug modifications, with the exception of compound 10 which exhibited some toxicity. This report also describes the synthesis of several aryl-alkyl and aryl-aryl carbonates (12- 14, 16-23) as efficient reagents for the preparation of carbamate derivatives from bis-arylamidines.