247091-95-8

Basic information

• Product Name: 2,4-difluoro-N-hydroxybenzimidoyl chloride
• Synonyms: 2,4-difluoro-N-hydroxybenzimidoyl chloride
• CAS NO: 247091-95-8
• Molecular Weight: 191.565
• Mol File: 247091-95-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2,4-difluoro-N-hydroxybenzimidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-difluoro-N-hydroxybenzimidoyl chloride(247091-95-8)
• EPA Substance Registry System: 2,4-difluoro-N-hydroxybenzimidoyl chloride(247091-95-8)

Safety Data

• Hazardous Substances Data: 247091-95-8(Hazardous Substances Data)

Upstream product

• 1550-35-2 2,4-difluorobenzaldehyde 
• 247092-11-1 2,4-difluoro-benzaldehyde oxime 

Downstream Products

• 334971-41-4 3-(2,4-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 1309794-05-5 (R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)acetic acid 
• 1309794-06-6 (R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone 
• 1309794-04-4 (1R,2S)-2-phenylcyclohexyl 2-((R)-3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)acetate 
• 897645-82-8 5-amino-3-(2,4-difluorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 159693-95-5 4-<4-(aminocarbonyl)-5-(chlorodifluoromethyl)-3-isoxazolyl>-5-fluoro-2-nitrophenoxyacetic acid ethyl ester 
• 159693-91-1 5-(chlorodifluoromethyl)-3-(2-fluoro-4-methoxy-5-nitrophenyl)-4-isoxazolecarboxylic acid methyl ester 
• 159693-89-7 methyl 5-(chlorodifluoromethyl)-3-(2,4-difluoro-5-nitrophenyl)-4-isoxazolecarboxylate 
• 159693-92-2 5-(chlorodifluoromethyl)-3-(2-fluoro-4-methoxy-5-nitrophenyl)-4-isoxazolecarboxylic acid 
• 159693-93-3 5-(chlorodifluoromethyl)-3-(2-fluoro-4-methoxy-5-nitrophenyl)-4-isoxazolecarboxamide 
• 159693-94-4 5-(chlorodifluoromethyl)-3-(2-fluoro-4-hydroxy-5-nitrophenyl)-4-isoxazolecarboxamide 

Relevant articles and documents

Palladium-Catalyzed Cyclization Reaction of Oxime Acetates and Aryl Iodides: Syntheses of 2-Imidazolines

A novel and versatile method for the synthesis of 2-imidazolines has been developed via the Pd-catalyzed cyclization reaction of readily available homoallenyl oxime acetates with aryl iodides. This protocol is performed under mild reaction conditions and needs no additives or ligands.

Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents

In order to develop novel antifungal agents, based on our previous work, a series of (2R,3R)-3-((3-substitutied-isoxazol-5-yl)methoxy)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (a1-a26) were designed and synthesized. All of the compounds exhibited good in vitro antifungal activities against eight human pathogenic fungi. Among them, compound a6 showed excellent inhibitory activity against Candida albicans and Candida parasilosis with MIC80 values of 0.0313 μg/mL. In addition, compounds a6, a9, a12, a13 and a14 exhibited moderate inhibitory activities against fluconazole-resistant isolates with MIC80 values ranging from 8 μg/mL to 16 μg/mL. Furthermore, compounds a6, a12 and a23 exhibited low inhibition profiles for CYP3A4. Clear SARs were analyzed, and the molecular docking experiment was carried out to further investigate the relationship between a6 and the target enzyme CYP51.

Triazole alcohol derivative and preparation method and application thereof

The invention relates to a triazole alcohol derivative and a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is as shown in the formula I. The invention also provides salt of the compound, a pharmaceutical composition, a preparation method and application. The compound of the invention has strong antifungal activity, has advantages of low toxicity and wide antimicrobial spectrum, and can be used for preparation of antifungal drugs.