247133-56-8Relevant articles and documents
Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.
Ueno, Hiroshi,Katoh, Susumu,Yokota, Katsuyuki,Hoshi, Jun-ichi,Hayashi, Mikio,Uchida, Itsuo,Aisaka, Kazuo,Hase, Yasunori,Cho, Hidetsura
, p. 4281 - 4286 (2007/10/03)
A series of benzimidazole derivatives with the side chain on the nitrogen atom oriented to the prime site of factor Xa (FXa) were designed and synthesized. Compounds with substituted aminocarbonylmethyl groups as the side chain showed potent FXa inhibitor