247193-74-4

Basic information

• Product Name: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID
• Synonyms: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID;1,4,7-tris-Boc-(10-carboxymethyl)-1,4,7,10-tetraaza-cyclododecan;(4,7,10-tris-Boc-1,4,7,10-tetraaza-cyclododecan-1-yl)-acetic acid;1,4,7-Tri-Boc-10-(carboxyMethyl)-1,4,7,10-tetraazacyclododecane;1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane 98% (TLC);1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-(carboxymethyl)-, 1,4,7-tris(1,1-dimethylethyl) ester;10-carboxymethyl-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester;1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane, 97.5%
• CAS NO: 247193-74-4
• Molecular Formula: C₂₅H₄₆N₄O₈
• Molecular Weight: 530.65
• Mol File: 247193-74-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 611.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.126±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID(247193-74-4)
• EPA Substance Registry System: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID(247193-74-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 247193-74-4(Hazardous Substances Data)

Usage

Description

(4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID, also known as 1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane, is a bifunctional chelating agent derived from the tetraazacyclodecane family. It is characterized by its white powder form and has the ability to form complexes with zinc ions (Zn(II)). These complexes exhibit unique properties, such as RNA-binding and antimicrobial activity, making it a versatile compound with potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
(4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID is used as a chelating agent for the formation of Zn(II) complexes, which exhibit antimicrobial properties. These complexes have potential applications in the development of new antimicrobial agents to combat drug-resistant bacteria and other pathogens.
Used in Molecular Biology:
(4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID is used as a building block to attach the Cyclen azacrown to a molecular scaffold. This attachment enables selective cleavage of the HIV-1 TAR-RNA with a peptide-cyclen conjugate, which can be beneficial in the development of targeted therapies for HIV and other RNA-based diseases.
Used in Chemical Synthesis:
(4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID serves as an important intermediate in the synthesis of various complex molecules and pharmaceutical compounds. Its unique structure and functional groups allow for further modification and incorporation into a wide range of molecules with diverse applications.

Upstream product

• 175854-39-4 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 294-90-6 1,4,7,10-tetraazacyclododecan 

Downstream Products

• 640731-06-2 methyl N²-[(benzyloxy)carbonyl]-N⁶-{[4,7,10-tris-(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetyl}-L-lysinate 
• 858642-02-1 4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane 
• 862097-47-0 10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester 
• 1173758-78-5 4,4'-bis[2-(N-{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclodecan-1-yl]acetyl}-N-phenethyl)aminoethoxy]diphenylmethane 
• 1609955-65-8 C₅₁H₈₈ClN₇O₁₀ 
• 1609955-66-9 C₅₅H₉₆ClN₇O₁₀ 
• 1609955-67-0 C₅₇H₁₀₀ClN₇O₁₀ 
• 1612753-17-9 tri-tert-butyl 10-(2-((4-methoxy-3,5-bis(methylcarbamoyl)benzyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate 

Relevant articles and documents

Selective cleavage of the HIV-1 TAR-RNA with a peptide-cyclen conjugate

Covalent linkage of the arginine-rich fragment of the Tat protein to 1,4,7,10-tetraazacyclododecane (cyclen) results in the selective cleavage of the TAR-RNA of HIV-1 (see picture; the biotin at the 5' end acts as a label for the subsequent analysis of the cleavage fragments). The cleavage occurs at room temperature and is diminished when Eu(III) ions are present - at a concentration of about 1/10 of the concentration of the peptide-cyclen conjugate. The pH dependence indicates that two ammonium ions are responsible for the cleavage reaction. The white arrows in the schematic diagram mark the cleavage sites in RNaseT1, and the black arrows the sites in the peptide- cyclen conjugate.

ANTIBACTERIAL COMPOUNDS

The invention relates to antibacterial compounds, methods for synthesis and use thereof in antibacterial applications.

Synthetic catalyst for selective cleavage of protein and method for selective cleavage of protein using the same

The present invention relates to a synthetic catalyst of the following formula (A) which can selectively recognize and cleave a specific protein among a protein mixture, and to a method for selective cleavage of a target protein using the same: (R)(Z)sub