247248-94-8

Basic information

• Product Name: 4,4-dimethyl-1-phenylpyrrolidine-2,3-dione
• Synonyms: 4,4-dimethyl-1-phenylpyrrolidine-2,3-dione
• CAS NO: 247248-94-8
• Molecular Weight: 203.241
• Mol File: 247248-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4-dimethyl-1-phenylpyrrolidine-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethyl-1-phenylpyrrolidine-2,3-dione(247248-94-8)
• EPA Substance Registry System: 4,4-dimethyl-1-phenylpyrrolidine-2,3-dione(247248-94-8)

Safety Data

• Hazardous Substances Data: 247248-94-8(Hazardous Substances Data)

Upstream product

• 70006-37-0 rac-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone 

Downstream Products

• 169221-12-9 (S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone 
• 169221-13-0 (R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one 

Relevant articles and documents

Enantioselective synthesis of both enantiomers of 3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone

The chiral auxiliaries (R)- and (S)-3-Hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone were obtained in good yield and e.e. by enantioselective reduction of 4,4-dimethyl-1-phenylpyrrolidine-2,3-dione with (-)- and (+)-B-chlorodiisopinocamphenylborane, (-)- and (+)-DIP-Chloride, respectively. The (R)-enantiomer was also obtained by enantioselective hydrogenation of the same precursor using a complex of 1,5-cyclooctadiene Rh(I) and (2S,4S)-1-(tert-butoxycarbonyl)-4-(diphenylphosphino)-2-(diphenylphosphinomethyl )pyrrolidine, (S,S)-BPPM, as the chiral catalyst.