2474-07-9Relevant articles and documents
Regioselective, Efficient and Sustainable Bromination Process for the Synthesis of the Antimicrobial Agent Bromiphen Bromide
Artasensi, Angelica,Pedretti, Alessandro,Vistoli, Giulio,Fumagalli, Laura
, p. 493 - 497 (2021)
-
An atom efficient synthesis of tamoxifen
Heijnen, Dorus,Van Zuijlen, Milan,Tosi, Filippo,Feringa, Ben L.
supporting information, p. 2315 - 2320 (2019/03/06)
The direct carbolithiation of diphenylacetylenes and their cross-coupling procedure taking advantage of the intermediate alkenyllithium reagents are presented. By employing our recently discovered highly active palladium nanoparticle based catalyst, we were able to couple an alkenyllithium reagent with a high (Z/E) selectivity (10:1) and good yield to give the breast cancer drug tamoxifen in just 2 steps from commercially available starting materials and with excellent atom economy and reaction mass efficiency.
Pd(OAc)2-Catalyzed Desulfinative Cross-Coupling of Sodium Sulfinates with β-Bromostyrenes: Synthesis of Tamoxifen
Chang, Meng-Yang,Cheng, Yu- Chieh,Sun, Pei- Pei
, p. 2411 - 2422 (2017/05/22)
A Pd(OAc)2-catalyzed desulfinative cross-coupling of (Z)-β-halostyrenes with sodium sulfinates in the presence of PPh3 and Na2CO3 at reflux in good yields is reported. The stereocontrolled cross-coupling process provides a series of sulfonylmethyl (Z)-stilbenes. A synthesis of tamoxifen was studied.