24764-40-7

Basic information

• Product Name: 1-TERT-BUTYLPYRROLE
• Synonyms: 1H-Pyrrole, 1-(1,1-dimethylethyl)-;1-(TERT-BUTYL)-1H-PYRROLE;1-TERT-BUTYLPYRROLE;Butylpyrrole;1-tert-Butylpyrrole,97%;1-TERT-BUTYLPYRROLE 97%;1-t-Butylpyrrole;1-(1,1-dimethylethyl)-1H-Pyrrole
• CAS NO: 24764-40-7
• Molecular Formula: C₈H₁₃N
• Molecular Weight: 123.2
• Mol File: 24764-40-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 153-155°C
• Flash Point: 48.4°C
• Appearance: /
• Density: 0,99 g/cm3
• Vapor Pressure: 3.73mmHg at 25°C
• Refractive Index: 1.47
• CAS DataBase Reference: 1-TERT-BUTYLPYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TERT-BUTYLPYRROLE(24764-40-7)
• EPA Substance Registry System: 1-TERT-BUTYLPYRROLE(24764-40-7)

Safety Data

• Statements: 10
• Safety Statements: 16-23-24/25
• RIDADR: 1993
• Hazardous Substances Data: 24764-40-7(Hazardous Substances Data)

Usage

General Description

1-TERT-BUTYLPYRROLE is a chemical compound with the molecular formula C9H15N. It is a pyrrole derivative that contains a tert-butyl group attached to the nitrogen atom. 1-TERT-BUTYLPYRROLE is often used in organic synthesis and as a building block for more complex molecules. It has a variety of potential applications in the pharmaceutical industry, particularly in the development of drugs for central nervous system disorders. 1-TERT-BUTYLPYRROLE exhibits unique properties and reactivity, making it a valuable tool for chemists and researchers in drug discovery and other areas of chemical science.

InChI:InChI=1/C8H13N/c1-8(2,3)9-6-4-5-7-9/h4-7H,1-3H3

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 75-64-9 tert-butylamine 
• 109-97-7 pyrrole 
• 463-82-1 2,2-dimethylpropane 
• 145939-75-9 1-formyl-2-chlorocyclopropane 
• 507-19-7 t-butyl bromide 

Downstream Products

• 23373-78-6 1-tert-Butyl-2-formyl-pyrrol 
• 74889-35-3 1-t-butyl-2-trifluoroacetylpyrrole 
• 74889-36-4 1-t-butyl-3-trifluoroacetylpyrrole 
• 1246213-58-0 1-tert-butyl-3-(1-cyclohexylmethyl)-1H-pyrrole 
• 1258287-86-3 (CH₃)3CNC₄H₄C(C₆H₅)CHB(C₆F₅)3*CH₂Cl₂ 
• 1258287-52-3 (CH₃)3CNC₄H₄C(C₆H₄CF₃)CHB(C₆F₅)3 
• 1258287-49-8 (CH₃)3CNC₄H₄C(C₆H₄Br)CHB(C₆F₅)3 
• 1258287-67-0 (CH₃)3CNC₆H₅(C₆H₅)2B(C₆F₅)2 
• 30186-46-0 1-(tert-butyl)-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

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Metal-free regioselective β-alkylation of pyrroles with carbonyl compounds and hydrosilanes: Use of a Bronsted acid as a catalyst

A Bronsted acid, trifluoromethanesulfonimide [HN(SO2CF3)2], was found to catalyze reductive β-alkylation of pyrroles with carbonyl compounds and hydrosilanes. This metal-free process features lower catalyst loadings compared to the original indium variant and exclusive generation of β-alkylpyrroles.

FORMATION OF 1-SUBSTITUTED PYRROLES IN REACTION OF 2-CHLOROCYCLOPROPANECARBOXALDEHYDES WITH PRIMARY AMINES

Reactions of 2-chlorocyclopropanecarboxaldehydes with primary amines in boiling DMF lead in good yield to 1-substituted pyrroles. 2-Chlorocyclopropanecarboxaldehydes were synthesized by the stereoselective reduction of the corresponding 2,2-dichlorocyclopropanemethanols with lithium tetrahydroaluminate with the subsequent oxidation of the mixture of stereoisomeric 2-chlorocyclopropanemethanols with pyridinium chlorochromate.