24772-63-2Relevant articles and documents
Highly Selective Radical Monoreduction of Dihalides Confined to a Dynamic Supramolecular Host
Petroselli, Manuel,Rebek, Julius,Yu, Yang
supporting information, p. 3284 - 3287 (2021/02/05)
Reduction of alkyl dihalide guests (2–5 and 7) with trialkylsilanes (R3SiH) was performed in water-soluble host 1 to investigate the effects of confinement on fast radical reactions (k≥103 m?1 s?1). High selectivity (>95 %) for mono-reduced products was observed for primary and secondary dihalide guests under mild conditions. The results highlight the importance of host–guest complexation rates to modulate the product selectivity in radical reactions.
Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site
Heydenreuter, Wolfgang,Kunold, Elena,Sieber, Stephan A.
supporting information, p. 15784 - 15787 (2015/11/10)
Falcarinol and stipudiol are natural products with potent anti-cancer activity found in several vegetables. Here, we use a chemical proteomic strategy to identify ALDH2 as a molecular target of falcarinol in cancer cells and confirm enzyme inhibition via covalent alkylation of the active site. Furthermore, the synthesis of stipudiol led to the observation that ALDH2 exhibits preference for alkynol-based binders. Inhibition of ALDH2 impairs detoxification of reactive aldehydes and limits oxidative stress response, two crucial pathways for cellular viability.
Low-Frequency Raman Spectra of Even α,ο-Disubstituted n-Alkanes
Viras, Kyriakos,Viras, Fontini,Campbell, Carl,King, Terence A.,Booth, Colin
, p. 3479 - 3483 (2007/10/02)
Low-frequency Raman spectra of even α,ο-disubstituted n-alkanes have been recorded.The major features in the spectra arise from whole-chain longitudinal and bending vibrations.The effects of end group, chain lenght, and temperature on the frequencies of these vibrations are described, and the frequencies of the longitudinal vibrations are interpreted in terms of the chain model of Minoni and Zerbi.