24775-57-3

Basic information

• Product Name: 1-naphthalen-1-yl-3-phenylthiourea
• Synonyms: thiourea, N-1-naphthalenyl-N'-phenyl-
• CAS NO: 24775-57-3
• Molecular Formula: C₁₇H₁₄N₂S
• Molecular Weight: 278.3715
• Mol File: 24775-57-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 442°C at 760 mmHg
• Flash Point: 221.1°C
• Density: 1.314g/cm³
• Vapor Pressure: 5.21E-08mmHg at 25°C
• Refractive Index: 1.795
• CAS DataBase Reference: 1-naphthalen-1-yl-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-naphthalen-1-yl-3-phenylthiourea(24775-57-3)
• EPA Substance Registry System: 1-naphthalen-1-yl-3-phenylthiourea(24775-57-3)

Safety Data

• Hazardous Substances Data: 24775-57-3(Hazardous Substances Data)

Usage

General Description

1-naphthalen-1-yl-3-phenylthiourea is a chemical compound that belongs to the class of thioureas. It is a white to off-white powder and is insoluble in water, but soluble in organic solvents. 1-naphthalen-1-yl-3-phenylthiourea is used in various industrial applications such as in the production of rubber chemicals, as a catalyst in the synthesis of organic compounds, and as a reagent in chemical reactions. It is also employed in the field of agriculture as a pesticide and herbicide. Furthermore, it has been studied for its potential pharmacological activities, including its anti-inflammatory and anti-cancer properties. However,

Upstream product

• 134-32-7 1-amino-naphthalene 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 551-06-4 1-isothiocyanatonaphthalene 
• 1240-37-5 N,N'-bis(1-naphthyl)thiourea 
• 29647-76-5 (naphth-1-ylamino)phenoxymethane-1-thione 
• 67-66-3 chloroform 

Downstream Products

• 21431-44-7 naphtho[1,2-d]thiazol-2-yl-phenyl-amine 
• 42135-78-4 4-(1-naphthyl)-3-thiosemicarbazide 
• 7669-41-2 (3-naphthalen-1-yl-4-oxo-2-phenylimino-thiazolidin-5-yl)-acetic acid 
• 14236-75-0 5-benzylidene-2-naphthalen-1-ylimino-3-phenyl-thiazolidin-4-one 
• 65672-98-2 naphthalen-1-yl-(3-phenyl-[1,3]thiazetidin-2-ylidene)-amine 
• 65672-97-1 (3-naphthalen-1-yl-[1,3]thiazetidin-2-ylidene)-phenyl-amine 
• 14230-07-0 (2-naphthalen-1-ylimino-4-oxo-3-phenyl-thiazolidin-5-ylidene)-acetic acid methyl ester 
• 111022-27-6 1-Naphthalen-1-yl-3-phenyl-thiourea; compound with 2,3-dicyano-but-2-enedinitrile 
• 134-32-7 1-amino-naphthalene 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 551-06-4 1-isothiocyanatonaphthalene 
• 111089-71-5 methyl-naphtho[1,2-d]thiazol-2-yl-phenyl-amine 
• 101601-72-3 1-(1-naphthyl)-N--phenyl-1H-tetrazol-5-amine 

Relevant articles and documents

A facile method for the preparation of carbodiimides from thioureas and (Boc)2O

A concise method for the preparation of carbodiimides from thioureas using di-tert-butyl dicarbonate [(Boc)2O] as the dehydrosulfurizative reagent has been developed. Using DMAP as the catalyst, a variety of symmetric and asymmetric 1,3-diaryl thioureas were converted into the corresponding carbodiimides efficiently in a short time.

Thiocarbonyl Surrogate via Combination of Sulfur and Chloroform for Thiocarbamide and Oxazolidinethione Construction

An efficient and practical thiocarbonyl surrogate via combination of sulfur and chloroform has been developed. A variety of thiocarbamides and oxazolidinethiones have been established, including chiral thiourea catalysts and chiral oxazolidinethione auxiliaries with high selectivity. Meanwhile, pesticides Diafenthiuron (an acaricide), ANTU (a rodenticide), and Chloromethiuron (an insecticide) were practically synthesized through this method in gram scale. Dicholorocarbene, as the key intermediate, was further confirmed via a carbene-trapping control experiment.

Convenient synthesis of unsymmetrical N,N′-disubstituted thioureas in water

A simple and convenient two-step method has been developed and used to synthesise 25 (4 of which are novel) unsymmetrical N,N′-disubstituted thioureas in water. Alkylamines or variously substituted arylamines reacted smoothly with phenyl chlorothionoformate at room temperature to form thiocarbamates, which were then reacted with another alkyl- or arylamine in water at reflux to afford the unsymmetrical N,N′-disubstituted thioureas in good to excellent yields. Mild conditions, simple work-up, high yields as well as using water as solvent are the major advantages of the method.