24789-88-6

Basic information

• Product Name: 2-(2-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one
• Synonyms: 2-(2-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one
• CAS NO: 24789-88-6
• Molecular Weight: 219.283
• Mol File: 24789-88-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one(24789-88-6)
• EPA Substance Registry System: 2-(2-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one(24789-88-6)

Safety Data

• Hazardous Substances Data: 24789-88-6(Hazardous Substances Data)

Upstream product

• 3626-62-8 2-phenyl-1-(1-piperidinyl)ethanone 
• 110-89-4 piperidine 
• 41696-96-2 C₈H₇ClO₂ 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 553-86-6 benzofuran-2(3H)-one 

Downstream Products

• 1599446-98-6 2-[2-(2-nitrophenoxy)phenyl]-1-(1-piperidyl)ethanone 
• 1599447-03-6 2-[2-(2-nitrophenoxy)phenyl]-2-(2-nitrophenyl)-1-(1-piperidyl)ethanone 
• 1599447-08-1 2-(2-hydroxyphenyl)-2-(2-nitrophenyl)-1-(1-piperidyl)ethanone 

Relevant articles and documents

Insights into Ruthenium(II/IV)-Catalyzed Distal C?H Oxygenation by Weak Coordination

C?H hydroxylation of aryl acetamides and alkyl phenylacetyl esters was accomplished via challenging distal weak O-coordination by versatile ruthenium(II/IV) catalysis. The ruthenium(II)-catalyzed C?H oxygenation of aryl acetamides proceeded through C?H ac

Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.

Developing the Scope of O→C Aryl Migrations: Exploring Amide Substrates as Potential Precursors for Asymmetric Reactions

A new and mild method for the production of diasteromerically enriched α-aryl carbonyl compounds has been achieved. Although only modest diastereoselectivies are observed, they demonstrate the potential of the method for further optimisation. It also appears that reactions that proceed through a five-membered spirocyclic transition state rearrange, whereas those proceeding through a six-membered transition state do not, but stop at the diaryl ether stage. A mild O→C aryl migration (Truce-Smiles rearrangement reaction) has been expanded to include amides as precursors, and it has been shown that the product ratios are dependent on the structure of the starting amides. Chiral auxiliaries have been incorporated in attempts to make the rearrangement asymmetric and modest diastereoselectivities were obtained.