2479-62-1Relevant articles and documents
Method for stably and efficiently preparing N-acrylamide compounds
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Paragraph 0039-0047, (2019/03/28)
The invention discloses a method for preparing N-acrylamide compounds, belonging to the field of chemical industry. The method comprises the steps of adding NH2-R2 or HCl.NH2-R2 into an alkaline aqueous solution, and then adding an organic solvent with a boiling point of lower than or equal to 85 DEG C or less so as to obtain reaction liquid; dropwise adding acryloyl chloride or methacryloyl chloride into the reaction liquid, and controlling the reaction temperature to be 5-15 DEG C and the reaction time to be 0.5-2h; carrying out rotary evaporation to remove the organic solvent and water so as to obtain a mixture of the N-acrylamide compounds and salt; precipitating the salt, and spin-drying the filtrate to obtain the N-acrylamide compounds. The method improves the stability of a reaction; furthermore, the boiling point of the mixed solvent is greatly reduced, so that the rotary evaporation with a higher dehydration speed does not cause polymerization, and the time for removing the solvent is greatly shortened. Furthermore, a purification method is optimized, so that the efficiency of a whole synthetic route is finally increased.
Well-defined synthetic polymers with a protein-like gelation behavior in water
Glatzel, Stefan,Badi, Nezha,Paech, Michael,Laschewsky, Andre,Lutz, Jean-Franois
supporting information; experimental part, p. 4517 - 4519 (2010/10/19)
Homopolymers of N-acryloyl glycinamide were prepared by reversible addition-fragmentation chain transfer polymerization in water. The formed macromolecules exhibit strong polymer-polymer interactions in aqueous milieu and therefore form thermoreversible physical hydrogels in pure water, physiological buffer or cell medium.