24793-01-9Relevant articles and documents
Novel substituted benzothiazole and Imidazo[2,1-b][1,3,4]Thiadiazole derivatives: Synthesis, characterization, molecular docking study, and investigation of their in vitro antileishmanial and antibacterial activities
Er, Mustafa,?zer, Arif,Direkel, ?ahin,Karakurt, Tuncay,Tahtaci, Hakan
, p. 284 - 296 (2019)
In this study, we synthesized new imidazo[2,1-b][1,3,4]thiadiazole derivatives containing benzothiazole group. To this end, we firstly obtained the benzo[d]thiazol-2-ylthio/oxy acetonitrile compounds (3a,b), the starting materials, in high yields (82% and 87%, respectively). Then, we synthesized the 2-amino-1, 3,4-thiadiazole derivatives (4a,b) from the reaction of these nitrile derivatives (3a,b) with thiosemicarbazide in trifluoroacetic acid (TFA) (in yields of 83% and 84%). Finally, we synthesized the imidazo[2,1-b][1,3,4]thiadiazole derivatives (5-24) containing benzothiazole group, which are the target compounds, from reactions of 2-amino-1,3,4-thiadiazole derivatives (4a,b) with phenacyl bromide derivatives (in yields of 53%–73%). All of the compounds synthesized were characterized with 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectroscopy. Antileishmanial and antibacterial activity tests were applied to the compounds synthesized in the study. It was observed that compound 8 had the highest antileishmanial activity (MIC = 10 000 μg/mL). Also, compounds 7 and 17 were found to be effective at the highest concentration studied (MIC = 20 000 μg/mL). In terms of antibacterial activity, compounds 4b and 7 were found to be the most effective compounds against Escherichia coli (MIC = 625 μg/mL). Theoretical calculations were performed to support the experimental results. To this end, we performed Molecular Docking studies to determine whether or not the compounds (4a, 4b, 7 and 13) optimized with Gaussian09 using the DFT/B3LYP/6-31G(d,p) theory, which is a quantum chemical calculation, could be an inhibitor agent for the 2eg7 Escherichia coli protein structure. Also, we investigated the relationship between the calculated HOMO values of these four ligands and docking studies.
Synthesis and E/Z configuration determination of novel derivatives of 3-Aryl-2-(benzothiazol-2′-ylthio) acrylonitrile, 3-(benzothiazol-2′- ylthio)-4-(furan-2′ ′-yl)-3-buten-2-one and 2-(1-(Furan-2′ ′-yl)-3′-oxobut-1′ ′-en-2-ylthio)-3-phenylquinazolin- 4(3H)-one
Al-Omran, Fatima,Mohareb, Rafat M.,El-Khair, Adel Abou
experimental part, p. 6129 - 6147 (2011/09/20)
Knoevenagel condensation of 2-(benzothiazol-2-ylthio) acetonitrile (2) with either furan-2-carbaldehyde or thiophene-2-carbaldehydes leads to E-isomers 4a-b exclusively, while the condensation of the compound 2 with benzaldehyde or parasubstituted benzaldehydes with an electron-donating group afforded E/Z mixtures 4c-e with preferentially formation of the E-isomer. Condensation of furan-2-carbaldehyde (3a) with either 1-(benzothiazol-2′-ylthio) propan-2-one (5) or 2-(2′-oxo propylthio)-3-phenylquinazolin- 4(3H)-one (9) leads exclusively to the Z-isomers of 6 and 10, respectively. The structures of the newly synthesized compounds were elucidated by elemental analyses, 1H-NMR and 13C-NMR spectra, COSY, HSQC, HMBC, NOE, MS and X-ray crystallographic investigations.
Electrolytic Partial Fluorination of Organic Compounds. 24.1 Highly Regioselective Anodic Monofluorination of 2-Benzothiazolyl and 5-Chloro-2-benzothiazolyl Sulfides
Hou, Yankun,Higashiya, Seiichiro,Fuchigami, Toshio
, p. 9173 - 9176 (2007/10/03)
Electrochemical fluorination of 2-benzothiazolyl and 5-chloro-2-benzothiazolyl sulfides was successfully carried out using Et4NF·3HF as a supporting electrolyte and fluoride ion source in dimethoxyethane to provide the corresponding α-monofluorinated sulfides in good yields. Fluorination took place selectively at the position α to the sulfur atom of the sulfides, and the heterocyclic moieties were not fluorinated at all.
