24797-40-8

Basic information

• Product Name: Benzene, 1-(2,2-dimethylpropyl)-4-methyl-
• CAS NO: 24797-40-8
• Molecular Formula: C12H18
• Molecular Weight: 162.275
• Mol File: 24797-40-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2,2-dimethylpropyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2,2-dimethylpropyl)-4-methyl-(24797-40-8)
• EPA Substance Registry System: Benzene, 1-(2,2-dimethylpropyl)-4-methyl-(24797-40-8)

Safety Data

• Hazardous Substances Data: 24797-40-8(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 
• 3282-30-2 pivaloyl chloride 
• 927-83-3 di-t-butyldiazene 
• 106-42-3 para-xylene 
• 108-88-3 toluene 
• 132907-18-7 3,6-dimethoxy-3,6-dimethylcyclohexa-1,4-diene 
• 594-19-4 tert.-butyl lithium 
• 104-82-5 4-Methylbenzyl chloride 
• 507-20-0 tertiary butyl chloride 

Downstream Products

• 136708-03-7 p-(2,2-dimethylpropyl)benzyl acetate 
• 136708-00-4 α-tert-butyl-p-methylbenzyl acetate 
• 32018-31-8 4-pivaloyl-benzoic acid 
• 65687-52-7 4-(2,2-dimethylpropyl)benzoic acid 

Relevant articles and documents

REACTIVITY OF 3,6-DIMETHOXY-3,6-DIMETHYLCYCLOHEXA-1,4-DIENE: NUCLEAR VERSUS BENZYLIC NUCLEOPHILIC SUBSTITUTION

The treatment of cis/trans-3,6-dimethoxy-3,6-dimethylcyclohexa-1,4-diene (ca. 1/1 mixture; easily prepared electrochemically in multigram scale from p-xylene) under acidic conditions (acetic, trifluoroacetic, sulfuric, or a Lewis acid) yields almost exclusively 2-methoxy-1,4-dimethylbenzene 4, through a trasposition reaction.The use of aqueous hydrochloric or hydrofluoric acid gives 2,5-dimethylphenol 12, and with hydrogen chloride a mixture of 2- and α-chloro-p-xylene (13, 14) is isolated.Different oxygen-, nitrogen-, and sulfur-containing nucleophiles (alcohols,thiols, or hydrazoic acid) react with 3 under acid catalysis giving the corresponding products resulting from a nuclear or/ and benzylic substitution on p-xylene (15 - 20).The reaction of compound 3 with organolithium reagents affords exclusively benzylic products 21 in a regiospecific manner.In all cases the mixtures of isomers are separated by column chromatography.The lithiation of compound 3 with lithium powder or lithium naphthalenide fails, giving p-xylene.A probable mechanism is proposed for the studied reactions.