24806-16-4

Basic information

• Product Name: Benzene, 1-(1,1-dimethylethyl)-4-(2-propenyloxy)-
• Synonyms: 1-allyloxy-4-tert-butylbenzene;allyl (4-tert-butylphenyl) ether;1-allyloxy-4-(1,1-dimethylethan-1-yl)benzene;p-cymyl 2-propenyl ether;allyl p-t-butylphenyl ether;allyl p-tert-butylphenyl ether;4-(tert-butyl)phenyl allyl ether;benzene,1-(1,1-dimethylethyl)-4-(2-propenyloxy)
• CAS NO: 24806-16-4
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Mol File: 24806-16-4.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1,1-dimethylethyl)-4-(2-propenyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1,1-dimethylethyl)-4-(2-propenyloxy)-(24806-16-4)
• EPA Substance Registry System: Benzene, 1-(1,1-dimethylethyl)-4-(2-propenyloxy)-(24806-16-4)

Safety Data

• Hazardous Substances Data: 24806-16-4(Hazardous Substances Data)

Upstream product

• 5787-50-8 sodium 4-tert-butylphenolate 
• 106-95-6 allyl bromide 
• 54932-87-5 1-(tert-butyl)-4-[(2-methylallyl)-oxy]benzene 
• 1215677-38-5 1-(tert-butyl)-4-(cinnamyloxy)benzene 
• 98-54-4 para-tert-butylphenol 
• 591-87-7 Allyl acetate 
• 107-05-1 3-chloroprop-1-ene 
• 557-40-4 Allyl ether 
• 107-18-6 allyl alcohol 
• 111865-33-9 (Z)-1-(tert-butyl)-4-(prop-1-en-1-yloxy)benzene 

Downstream Products

• 98-54-4 para-tert-butylphenol 
• 23431-48-3 allyl p-tolyl ether 
• 34911-36-9 4-(tert-butyl)-2,6-di(prop-2-en-1-yl)phenol 
• 94374-53-5 2-allyl-4-(tert-butyl)phenyl allyl ether 
• 23473-74-7 2-allyl-4-tert-butylphenol 

Relevant articles and documents

Nickel-catalyzed deallylation of aryl allyl ethers with hydrosilanes

An efficient and mild catalytic deallylation method of aryl allyl ethers is developed, with commercially available Ni(COD)2 as catalyst precursor, simple substituted bipyridine as ligand and air-stable hydrosilanes. The process is compatible with a variety of functional groups and the desired phenol products can be obtained with excellent yields and selectivity. Besides, by detection or isolation of key intermediates, mechanism studies confirm that the deallylation undergoes η3-allylnickel intermediate pathway.

Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta

Cardiovascular diseases (CVDs) present high prevalence rates in the current world. It is estimated that approximately one-third of the global deaths are related to CVDs, and thus there is still a need for novel drugs to treat these disorders. We serendipitously discovered that LINS01005 (5a) is a potent vasodilating agent in rat aorta, and therefore a set of analogues were evaluated for the vasodilating potency in Wistar and SHR rat thoracic aorta precontracted with norepinephrine, with endothelium intact (E+) or denuded (E–) aortic rings. Compounds 5a and 5b were the most potent, showing submicromolar potency for endothelium intact vessels (EC50 853 and 941 nM, respectively) and micromolar values for E– vessels (EC50 2.4 and 7.1 μM, respectively). These compounds were indeed significantly more potent vasodilating agents in SHR-derived aortic rings (p 50 2.4 nM (E+) 9.0 nM (E–)] and 5b [EC50 20 nM (E+) 2.1 μM (E–)]. SAR analysis though PCA and HCA were performed, suggesting that N-phenylpiperazine is essential to the activity, while increasing volume in the substituted aromatic moiety is detrimental to the potency. This is the first report of the vasodilating properties of such compounds, and studies regarding the mechanism of action are in progress in our group.

Enantioselective Construction of Si-Stereogenic Center via Rhodium-Catalyzed Intermolecular Hydrosilylation of Alkene

Catalytic, enantioselective synthesis of stereogenic silicon compounds remains a challenge. Herein, we report a rhodium-catalyzed regio- and enantio-selective intermolecular hydrosilylation of alkene with prochiral dihydrosilane. This new method features a simple catalytic system, mild reaction conditions and a wide functional group tolerance.