24806-95-9Relevant articles and documents
Structural effects on the phosphorylation of 3-substituted 1-β-d-ribofuranosyl-1,2,4-triazoles by human adenosine kinase
Kumarapperuma, Sidath C.,Sun, Yanjie,Jeselnik, Marjan,Chung, Kiwon,Parker, William B.,Jonsson, Colleen B.,Arterburn, Jeffrey B.
, p. 3203 - 3207 (2007)
The conversion of ribavirin to the monophosphate by adenosine kinase is the rate-limiting step in activation of this broad spectrum antiviral drug. Variation of the 3-substituents in a series of bioisosteric and homologated 1-β-d-ribofuranosyl-1,2,4-triazoles has marked effects on activity with the human adenosine kinase, and analysis of computational descriptors and binding models offers insight for the design of novel substrates.