2482-25-9 Usage
Description
4-HYDROXY-BZ-GLY-OH, also known as 4-Hydroxyhippuric acid, is an N-acylglycine derivative that is the 4-hydroxy derivative of hippuric acid. It is a beige powder in appearance and is used in various applications due to its unique chemical properties.
Uses
Used in Pharmaceutical Research:
4-HYDROXY-BZ-GLY-OH is used as a probe for estimating the activities of organic anion transporter 3 (OAT3) and multidrug resistance-associated protein 4 (MRP4). These proteins are responsible for mediating the efflux of organic anions from the brain and heart in mice. The compound helps researchers understand the transport mechanisms and develop potential treatments for related conditions.
Used in Neurological Applications:
In the field of neurology, 4-HYDROXY-BZ-GLY-OH is used to study the transport of organic anions across the blood-brain barrier. This understanding can be crucial for the development of drugs that target the central nervous system and require efficient crossing of this barrier.
Used in Cardiology Applications:
In cardiology, 4-HYDROXY-BZ-GLY-OH is utilized to investigate the transport of organic anions in the heart. This can aid in the development of therapies for heart-related conditions that involve the movement of these anions across cellular membranes.
Used in Drug Development:
4-HYDROXY-BZ-GLY-OH is also used in the development of drugs that target the transporters OAT3 and MRP4. By understanding the interaction between these transporters and the compound, researchers can design drugs that are more effective in crossing cellular barriers and reaching their target sites.
Check Digit Verification of cas no
The CAS Registry Mumber 2482-25-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2482-25:
(6*2)+(5*4)+(4*8)+(3*2)+(2*2)+(1*5)=79
79 % 10 = 9
So 2482-25-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
2482-25-9Relevant articles and documents
Synthesis of 4-hydroxybenzamides and their salts
Brel,Lisina,Budaeva, Yu. N.,Popov
, p. 2200 - 2202 (2015)
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Substrate Specificity and Stoichiometry of Nα-Benzyloxycarbonyl Amino Acid Urethane Hydrolase from Streptococcus faecalis R ATCC 8043
Matsumura, Eiko,Shin, Takashi,Murao, Sawao,Kawano, Tatsu
, p. 973 - 980 (2007/10/02)
The substrate specificity of a new enzyme, Nα-benzyloxycarbonyl amino acid urethane hydrolase, was investigated.The enzyme hydrolyzed Nα-benzyloxycarbonyl-glycine and -alanine, and Nα-benzoyl-glycine and -alanine.Nα-benzyloxycarbonyl-glycine was hydrolyzed to give equimolar benzyl alcohol and glycine.Equimolar benzoic acid and glycine were produced from Nα-benzoyl-glycine by the enzyme reaction.The Km, k0, and k0/Km values were measured for several substrates.The k0 values varied widely with the amino acid residues.Nα-benzyloxycarbonyl-glycine and Nα-benzoyl-glycine produced relatively small changes in the Km values (0.36 ca. 0.10 mM) and the k0/Km values (99440 ca. 202000 M-1 sec-1).The rate of hydrolysis is significantly affected by electron-supplying substituents on the benzene ring.
