24827-66-5

Basic information

• Product Name: 1-methyl-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide
• Synonyms: 1-methyl-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide
• CAS NO: 24827-66-5
• Molecular Formula: C₈H₉NO₂S
• Molecular Weight: 183.22756
• Mol File: 24827-66-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-methyl-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide(24827-66-5)
• EPA Substance Registry System: 1-methyl-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide(24827-66-5)

Safety Data

• Hazardous Substances Data: 24827-66-5(Hazardous Substances Data)

Upstream product

• 111248-89-6 1,3-dihydro-2,1-benzisothiazole 2,2-dioxide 
• 74-88-4 methyl iodide 
• 89665-79-2 (2-chlorophenyl)-methanesulfonamide 
• 111249-29-7 2-aminobenzylsulfonic acid sodium salt 
• 77421-13-7 (2-chlorobenzyl)sulfonyl chloride 
• 615-36-1 2-bromoaniline 
• 116547-91-2 N-(2-bromophenyl)methanesulfonamide 
• 553652-34-9 N-(2-bromophenyl)-N-methylmethanesulfonamide 

Downstream Products

• 187333-17-1 1-methyl-3-(4-nitrophenyl)-1,3-dihydro-2,1-benzisothiazole 2,2-dioxide 
• 57503-00-1 N-o-tolyl-methanimine 
• 623159-68-2 3-(3-chloro-4-nitrophenyl)-1-methyl-1,3-dihydro-2,1-benzisothiazole 2,2-dioxide 
• 16367-94-5 2-(1H-benzo[d]imidazol-2-yl)-N-methylaniline 
• 73480-69-0 N-methyl-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)aniline 
• 5339-28-6 N-methyl-N-(2-vinylphenyl)amine 

Relevant articles and documents

Synthesis of Oxindole Derivatives via Intramolecular C–H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst

This work presented the efficient intramolecular aromatic C–H insertion of diazoacetamide. The 1a–1o diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramolecular C–H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min?1 (TOF).

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene. Here we report the discovery of 109 (CCT251921), a potent, selective, and orally bioavailable inhibitor of CDK8 with equipotent affinity for CDK19. We describe a structure-based design approach leading to the discovery of a 3,4,5-trisubstituted-2-aminopyridine series and present the application of physicochemical property analyses to successfully reduce in vivo metabolic clearance, minimize transporter-mediated biliary elimination while maintaining acceptable aqueous solubility. Compound 109 affords the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer.

2-AMINOPYRIDINE COMPOUNDS

The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.