248270-25-9 Usage
Description
3-Fluoro-4-formylphenylboronic acid is an organic compound that features a boronic acid group, a formyl group, and a fluorine atom attached to a phenyl ring. It is a white to light yellow crystalline powder and is known for its reactivity in various chemical reactions.
Uses
Used in Chemical Synthesis:
3-Fluoro-4-formylphenylboronic acid is used as a reactant for the preparation of MIDA boronates, which are essential in Suzuki-Miyaura cross-coupling reactions. These reactions are widely employed in the synthesis of complex organic molecules, including pharmaceuticals and advanced materials.
Used in Pharmaceutical Industry:
3-Fluoro-4-formylphenylboronic acid is used as a key intermediate in the synthesis of pyrazolopyrimidinamine derivatives. These derivatives have potential applications as inhibitors of tyrosine and phosphinositide kinases, which are important targets for the development of new drugs to treat various diseases, including cancer and inflammatory disorders.
Used in Suzuki Reaction:
In the field of organic chemistry, 3-Fluoro-4-formylphenylboronic acid is used as a reactant in Suzuki reactions. This type of reaction is a widely used method for the formation of carbon-carbon bonds, particularly in the synthesis of biaryl compounds, which are prevalent in pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 248270-25-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,8,2,7 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 248270-25:
(8*2)+(7*4)+(6*8)+(5*2)+(4*7)+(3*0)+(2*2)+(1*5)=139
139 % 10 = 9
So 248270-25-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BFO3/c9-7-3-6(8(11)12)2-1-5(7)4-10/h1-4,11-12H
248270-25-9Relevant articles and documents
Intermediate, and synthetic method and application for intermediate
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Paragraph 0077; 0078; 0129; 0130; 0142, (2018/09/11)
The invention provides an intermediate compound, and a synthetic method and an application for the intermediate compound. The method comprises the following steps: dissolving a compound 4 in water, then adding an obtained mixture into a tC18 column, flushing the column with water, and carrying out blowing with gas so as to discharge an excess liquid; adding an NaBH4 aqueous solution, carrying outa reaction for 2 minutes or above, flushing the column with water, and carrying out blowing with gas so as to discharge an excess liquid; and adding an HI aqueous solution, carrying out a reaction for2 minutes or above, discharging an excess liquid by using gas, and carrying out elution with toluene so as to obtain an intermediate compound dissolved toluene solution, wherein the mole ratio of thecompound 4 to NaBH4 to HI is 1: (1-5): (1-5). The intermediate compound provided by the invention is mainly applied to F-BPA nucleophilic fluorination synthesis.
