24880-40-8 Usage
Description
8Z,11Z,14Z,17Z-Eicosatetraenoic Acid, also known as (all-cis)-8,11,14,17-Eicosatetraenoic Acid or ω-3 Arachidonic Acid, is a rare polyunsaturated fatty acid (PUFA) that is found in trace amounts in dietary sources. It is an essential nutrient for infant growth and development and offers protection against various health conditions, including heart disease, hypertension, thrombosis, and autoimmune and inflammatory disorders. In human platelet membranes, it has been shown to inhibit arachidonoyl-CoA synthetase, a key enzyme in fatty acid metabolism.
Uses
Used in Pharmaceutical Applications:
8Z,11Z,14Z,17Z-Eicosatetraenoic Acid is used as a therapeutic agent for promoting infant development and supporting overall health. Its essential role in growth and development makes it a crucial component in the diet of infants and young children.
Used in Cardiovascular Health:
8Z,11Z,14Z,17Z-Eicosatetraenoic Acid is used as a preventative measure for heart disease, hypertension, and thrombosis. Its presence in the diet helps to maintain a healthy cardiovascular system and reduce the risk of these conditions.
Used in Anti-Inflammatory and Autoimmune Applications:
8Z,11Z,14Z,17Z-Eicosatetraenoic Acid is used as a treatment for inflammatory and autoimmune disorders due to its ability to modulate the immune system and reduce inflammation.
Used in Platelet Membrane Function:
8Z,11Z,14Z,17Z-Eicosatetraenoic Acid is used as a regulator of platelet membrane function, as it inhibits arachidonoyl-CoA synthetase, which plays a role in the synthesis of eicosanoids, signaling molecules involved in various physiological processes, including blood clotting and inflammation.
Used in Research and Development:
8Z,11Z,14Z,17Z-Eicosatetraenoic Acid is used as a research tool for studying the role of ω-3 fatty acids in various biological processes and their potential applications in the development of new therapeutic strategies for a range of health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 24880-40-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,8,8 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24880-40:
(7*2)+(6*4)+(5*8)+(4*8)+(3*0)+(2*4)+(1*0)=118
118 % 10 = 8
So 24880-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h12-19H,2-11H2,1H3,(H,21,22)/b13-12-,15-14u,17-16u,19-18u
24880-40-8Relevant articles and documents
Synthesis of Rare Polyunsaturated Fatty Acids: Stearidonic and ω-3 Arachidonic
Golovanov,Ivanov,Groza,Myagkova
, p. 1038 - 1041 (2016/02/18)
Total chemical syntheses of the rare natural ω-3 C18 and C20 fatty acids, which possess potential antiinflammatory activity, were elaborated for subsequent studies of their biological activity.
Chemical C2-elongation of polyunsaturated fatty acids
Kuklev, Dmitry V.,Smith, William L.
, p. 172 - 177 (2007/10/03)
Three fatty acids were synthesized from commercially available α-linolenic, stearidonic and eicosapentaenoic acids by C2-elongation using a four step preparative technique. The parent fatty acid methyl esters were reduced to alcohols with LiAlH4, converted to bromides by treatment with triphenylphosphine dibromide, coupled with a lithiated C2-elongation block - 2,4,4-trimethyl-2-oxazoline - to form the corresponding 2,2-dimethyloxazolines of C2-elongated fatty acids, and finally, converted to the target polyunsaturated fatty acids by acidic alcoholysis. Yields of more than 60% were achieved on a gram scale. The resulting 11Z,14Z,17Z-eicosatrienoic, 8Z,11Z,14Z,17Z-eicosatetraenoic and 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acids were obtained as colorless oils with >98% purity and could be used for biochemical investigations without additional purification. The elongated fatty acids were free of byproducts that could result from Z-E isomerization or migration of double bonds.
