24880-52-2

Basic information

• Product Name: 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine
• Synonyms: 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine
• CAS NO: 24880-52-2
• Molecular Weight: 552.633
• Mol File: 24880-52-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine(24880-52-2)
• EPA Substance Registry System: 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine(24880-52-2)

Safety Data

• Hazardous Substances Data: 24880-52-2(Hazardous Substances Data)

Upstream product

• 31598-80-8 2,3,5-Tri-O-benzyl-1-O-(p-nitrobenzoyl)-β-D-arabinofuranose 
• 135840-51-6 2,6-Di(methoxyacetamido)-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)purine 

Downstream Products

• 24649-69-2 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine 
• 78842-13-4 2'-deoxy-2'-fluoroguanosine 
• 80681-25-0 2’-fluoro-N2-isobutyryl-2’-deoxyguanosine 
• 38819-10-2 9-β-D-arabinofuranosylguanine 

Relevant articles and documents

Hydrogenation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine

A process for the preparation of 2-fluoro-9-beta-D-arabinofuranosyl purine (VII) by a reaction of palladium chloride and hydrochloric acid with 2-fluoro-9-(2,3,5-tribenzyl-beta-D-arabinofuranosyl)adenine (VI) at elevated pressures in a solvent for (VI) is described. The reaction is rapid, economical and efficient.

Process for the preparation of 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl) adenine and novel intermediates

A process for the preparation of 2,6-diamino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)purine (V) by reacting 2,6-di(alkoxyacetamido)purine (II) with 2,3,5-tri-O-benzyl-1-chloro-alpha-D-arabinofuranose (III) to produce 2,6-di(alkoxyacetamido)-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)purine (IV) and then deprotecting the 2,6-positions to produce the 2,6-diamine (V) is described. The process provides purine (V) in high yield. Purine (V) is an intermediate in the preparation of 9-beta-D-arabinofuranosyl-2-fluoroadenine which is a cytotoxic agent.

An improved procedure for the preparation of 9-β-D-Arabinofuranosyl-2-fluoroadenine

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