248924-35-8

Basic information

• Product Name: 2-(benzhydrylidene-amino)-3-[2,3']bipyridinyl-5-yl-propionic acid ethyl ester
• CAS NO: 248924-35-8
• Molecular Weight: 435.525
• Mol File: 248924-35-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(benzhydrylidene-amino)-3-[2,3']bipyridinyl-5-yl-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzhydrylidene-amino)-3-[2,3']bipyridinyl-5-yl-propionic acid ethyl ester(248924-35-8)
• EPA Substance Registry System: 2-(benzhydrylidene-amino)-3-[2,3']bipyridinyl-5-yl-propionic acid ethyl ester(248924-35-8)

Safety Data

• Hazardous Substances Data: 248924-35-8(Hazardous Substances Data)

Upstream product

• 69555-14-2 ethyl N-diphenylmethylene glycine 
• 101990-45-8 2-bromo-5-bromomethylpyridine 
• 1692-25-7 3-pyridylboronic acid 
• 248924-16-5 2-(benzhydrylidene-amino)-3-(6-bromo-pyridin-3-yl)-propionic acid ethyl ester 

Relevant articles and documents

Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1

Directed screening of metalloprotease inhibitors identified CGS 30084 (1) as a potent inhibitor of endothelin-converting enzyme-1 (ECE-1) in vitro (IC50=77 nM). Herein we report the syntheses and biological activities of analogues containing modified biphenyl moieties, bearing heterocyclic proximal rings. Compound 20, the thioacetate ethyl ester prodrug derivative of compound 19a, was found to be an orally active and potent inhibitor of ECE-1 activity in rats.