24922-01-8

Basic information

• Product Name: 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: ETHYL 3-CYCLOBUTYL-3-OXOPROPANOATE;3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
• CAS NO: 24922-01-8
• Molecular Formula: C₉H₁₄O₃
• Molecular Weight: 170.21
• Mol File: 24922-01-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 234.5°C at 760 mmHg
• Flash Point: 95.7°C
• Appearance: /
• Density: 1.096g/cm³
• Vapor Pressure: 0.0526mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: 2-8°C
• PKA: 10.51±0.20(Predicted)
• CAS DataBase Reference: 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER(24922-01-8)
• EPA Substance Registry System: 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER(24922-01-8)

Safety Data

• Hazardous Substances Data: 24922-01-8(Hazardous Substances Data)

Usage

General Description

3-Cyclobutyl-3-oxo-propionic acid ethyl ester is a chemical compound that belongs to the class of cyclobutane carboxylic acid esters. It is commonly used as a building block in the synthesis of pharmaceuticals and fine chemicals. 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER has the molecular formula C9H14O3 and a molecular weight of 170.21 g/mol. It appears as a clear, colorless liquid with a faint odor, and it is soluble in organic solvents. 3-Cyclobutyl-3-oxo-propionic acid ethyl ester is primarily used in the production of drugs and can also be employed as a flavor or fragrance ingredient in various products. It is important to handle this chemical with care as it may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C9H14O3/c1-2-12-9(11)6-8(10)7-4-3-5-7/h7H,2-6H2,1H3

Upstream product

• 855384-50-8 2-cyclobutanecarbonyl-3-oxo-butyric acid ethyl ester 
• 1071-46-1 hydrogen ethyl malonate 
• 5006-22-4 Cyclobutanecarbonyl chloride 
• 6148-64-7 ethyl potassium malonate 
• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 3721-95-7 Cyclobutanecarboxylic acid 
• 3019-25-8 1-cyclobutylethanone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 1335027-51-4 ethyl 3-cyclobutyl-2-[(3,4-dichlorophenyl)methyl]-3-oxopropanoate 
• 1335027-54-7 ethyl 2-[(3-chlorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate 
• 1335027-52-5 ethyl 3-cyclobutyl-2-[(3,4-difluorophenyl)methyl]-3-oxopropanoate 
• 1335027-56-9 ethyl 3-cyclobutyl-2-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}-3-oxopropanoate 
• 1335027-58-1 ethyl 2-[(4-chloro-3-fluoro-phenyl)methyl]-3-cyclobutyl-3-oxo-propanoate 
• 1335027-55-8 ethyl 2-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-3-cyclobutyl-3-oxo-propanoate 
• 1335027-53-6 ethyl 2-[(3-chloro-4-fluorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate 

Relevant articles and documents

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

Synthesis of the 1,3,4-Oxadiazole Core through Thermolysis of Geminal Diazides

The thermolysis of geminal diazides derived from acylacetate compounds is an efficient tool for the rapid construction of the 1,3,4-oxadiazole core. While a broad range of ethyl esters undergoes smooth transformation to the desired heterocycles that contain the ester moiety in moderate to high yields, the analogous tert-butyl esters give rise to the oxadiazoles with acyl groups, presumably through a pathway of decarboxylation followed by a new acyl transfer.

FARNESOID X RECEPTOR AGONISTS

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