2493-31-4Relevant articles and documents
Fluoromethyl-2,4,6-trinitrophenylsulfonate: A New Electrophilic Monofluoromethylating Reagent
Reichel, Marco,Sile, Sami,Kornath, Andreas,Karaghiosoff, Konstantin
, p. 4423 - 4431 (2021/04/06)
Fluoromethyl-2,4,6-trinitrophenylsulfonate has been prepared for the first time and qualified as a simple to use monofluoromethylating reagent. Its molecular structure in the solid state has been determined by single-crystal X-ray diffraction studies. This reagent proves to be effective for the electrophilic introduction of a CH2F group into selected chalcogen and nitrogen nucleophiles. Monofluoromethyl derivatives of various bifunctional N,O-nucleophiles have been synthesized using fluoromethyl-2,4,6-trinitrophenylsulfonate. Due to the good crystallizing properties of the anion, the fluoromethylated products as well as side products that are difficult to identify by nuclear magnetic resonance spectroscopy can readily be characterized by X-ray crystallographic techniques.
AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS OF ACTIVATED N-ARYLPYRAZOLES WITH FORMAMIDES
Chiriac, Constantin I.,Lupu, Viorel,Chiriac, Florentina,Ropot, Radu,Tibirna, Mihaela,Truscan, Ion
, p. 549 - 553 (2007/10/03)
Different activated N-arylpyrazoles, as N-(2',4'-dinitrophenyl)-3,5-dimethylpyrazole, N-picryl-3,5-dimethylpyrazole etc., can react with excess formamides, as formamide N-methylformamide and N,N-dimethylformamide, at 165-175 deg C, for 5-6 hours, resulting amines in high yieds.This reaction is influenced by steric hindrance.
REACTION OF BIS(2,4,6-TRINITROPHENYL) SULFONE AND ITS DERIVATIVES WITH AMINES
Nurgatin, V. V.,Sharnin, G. P.,Nurgatina, R. B.,Ginzburg, B. M.
, p. 306 - 309 (2007/10/02)
The reaction of bis(2,4,6-trinitrophenyl) sulfone and some of its 3- and 3,3'-substituted derivatives with organic bases leads to the formation of an adduct of 1,3,5-trinitrobenzene or its substituted derivative and the respective amine, sulfur trioxide, and 2,4,6-trinitrodiphenylamine and its derivatives or derivatives of 2,4,6-trinitroaniline.The direction of reaction does not depend on the ratio of the initial compounds or on the temperature.It was established that attack by the nucleophilic reagent takes place at the ring in which the largest positive charge is induced at the carbon atom attached to the sulfur.