24974-75-2 Usage
Description
2-Nitro-α-toluenesulfonyl chloride, also known as 2-Nitro-Tosyl chloride, is a sulfonyl halide that is widely used in organic synthesis and pharmaceutical chemistry. It is characterized by its reactivity and ability to form various chemical bonds, making it a versatile compound in the field of chemistry.
Uses
Used in Pharmaceutical Industry:
2-Nitro-α-toluenesulfonyl chloride is used as a reagent for the preparation of novel pyridinioalkanoyl thiolesters (PATE), which are known to exhibit anti-HIV-1 properties. Its role in the synthesis of these compounds is crucial, as it contributes to the development of potential therapeutic agents against the virus.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Nitro-α-toluenesulfonyl chloride is employed as a protecting group for amines and alcohols. Its ability to form stable bonds with these functional groups allows chemists to protect them during various reaction conditions, ensuring the selective functionalization of other groups in the molecule.
Used in Chemical Research:
2-Nitro-α-toluenesulfonyl chloride is also utilized in chemical research for the synthesis of various complex organic molecules and pharmaceutical compounds. Its unique reactivity and compatibility with a wide range of reaction conditions make it a valuable tool for researchers in the development of new chemical entities and potential drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 24974-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,9,7 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 24974-75:
(7*2)+(6*4)+(5*9)+(4*7)+(3*4)+(2*7)+(1*5)=142
142 % 10 = 2
So 24974-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO4S/c8-14(12,13)5-6-3-1-2-4-7(6)9(10)11/h1-4H,5H2
24974-75-2Relevant articles and documents
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγInverse Agonist for Treatment of Castration-Resistant Prostate Cancer
Zhang, Yan,Wu, Xishan,Xue, Xiaoqian,Li, Chenchang,Wang, Junjian,Wang, Rui,Zhang, Cheng,Wang, Chao,Shi, Yudan,Zou, Lingjiao,Li, Qiu,Huang, Zenghong,Hao, Xiaojuan,Loomes, Kerry,Wu, Donghai,Chen, Hong-Wu,Xu, Jinxin,Xu, Yong
, p. 4716 - 4730 (2019/05/08)
We report the design, optimization, and biological evaluation of nuclear receptor RORγinverse agonists as therapeutic agents for prostate cancer treatment. The most potent compound 27 (designated as XY101) exhibited cellular activity with an IC50/su
